Первинна оцінка впливу частково гідрованих похідних 3-ацетилізокумарину на ріст ракових клітин
In different conditions, from 3-acetyl-1H-isochromen-1-one three partial reduction products were obtained, namely 3-(1-hydroxyethyl)-1H-isochromen-1-one, 3-(1-hydroxyethyl)isochroman-1-one, and 3-ethylisochroman-1-one. The influence of two products with an alcohol fragment, as well as 4-hydroxy-1,2,...
Збережено в:
| Дата: | 2024 |
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| Автори: | , , |
| Формат: | Стаття |
| Опубліковано: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2024
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| Теми: | |
| Онлайн доступ: | https://bioorganica.com.ua/index.php/journal/article/view/88 |
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| Назва журналу: | Ukrainica Bioorganica Acta |
Репозитарії
Ukrainica Bioorganica Acta| Резюме: | In different conditions, from 3-acetyl-1H-isochromen-1-one three partial reduction products were obtained, namely 3-(1-hydroxyethyl)-1H-isochromen-1-one, 3-(1-hydroxyethyl)isochroman-1-one, and 3-ethylisochroman-1-one. The influence of two products with an alcohol fragment, as well as 4-hydroxy-1,2,3,4-tetrahydro-6H-benzo[c]chromen-6-one, on the growth of cancer cells was investigated through One Doses Full NCI 60 Cell Panel Assay. The only one significant effect was found: 3-(1-hydroxyethyl)-1H-isochromen-1-one practically stops the growth of CCRF-CEM cell lines (Leukemia) |
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