Синтез та вивчення протигрибкової активності похідних 1,3-тіазол-2-іл гідразидів ароматичних альдегідів
A number of 1,3-thiazol-2-yl hydrazones of aromatic aldehydes were synthesized and tested for antifungal activity. It was found two promising compounds: 2-[(1Z)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]pyridine has MIC of 8 μg/ml against Cryptococcus neoformans and MIC of 16 μg/ml aga...
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| Datum: | 2024 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2024
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| Schlagworte: | |
| Online Zugang: | https://bioorganica.com.ua/index.php/journal/article/view/90 |
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| Назва журналу: | Ukrainica Bioorganica Acta |
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Ukrainica Bioorganica Acta| Zusammenfassung: | A number of 1,3-thiazol-2-yl hydrazones of aromatic aldehydes were synthesized and tested for antifungal activity. It was found two promising compounds: 2-[(1Z)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]pyridine has MIC of 8 μg/ml against Cryptococcus neoformans and MIC of 16 μg/ml against Candida albicans and 4-[(1Z)-{2-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazin-1-ylidene}methyl]-2,6-dimethoxy-phenol has MIC of 0.5 μg/ml against Cryptococcus neoformans, respectively |
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