Синтез та дослідження протигрибкових властивостей похідних (1Z)-[2-(1,3-тіазол-2-іл)гідразин-1-іліден]метилу
A number of (1Z)-[2-(1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl derivatives were synthesized and tested for antifungal properties. It was found that the compound 2-[(1Z)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]pyridine had an MIC of 8 μg/ml against Cryptococcus neoformans and an MIC...
Збережено в:
| Дата: | 2024 |
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| Автори: | , , , |
| Формат: | Стаття |
| Опубліковано: |
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
2024
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| Онлайн доступ: | https://bioorganica.com.ua/index.php/journal/article/view/90 |
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| Назва журналу: | Ukrainica Bioorganica Acta |
Репозитарії
Ukrainica Bioorganica Acta| Резюме: | A number of (1Z)-[2-(1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl derivatives were synthesized and tested for antifungal properties. It was found that the compound 2-[(1Z)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]pyridine had an MIC of 8 μg/ml against Cryptococcus neoformans and an MIC of 16 μg/ml against Candida albicans. Two compounds 4-[(1Z)-{2-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazin-1-ylidene}methyl]-2,6-dimethoxyphenol and 2-bromo-6-methoxy-4-[(1E)-[2-(4-methyl-1,3-thiazol-2-yl)hydrazin-1-ylidene]methyl]phenol have MIC of 0.5 μg/ml and 32 μg/ml against Cryptococcus neoformans, respectively |
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