Межі застосування частково ненасичених сультамів як дієнофілів і дієнів у реакції [4+2] циклоприєднання Дільса-Альдера

• Date: 2025
• Author Affiliations: Illia O. Borodin — Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Ltd, Kyiv, Ukraine; Yevhen O. Zaika — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Enamine Ltd., Kyiv, Ukraine; Volodymyr S. Brovarets — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Illia O. Doroshenko — Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Ltd, Kyiv, Ukraine; Oleksandr O. Grygorenko — Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Ltd, Kyiv, Ukraine; Bohdan V. Vashchenko — Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Enamine Ltd, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Borodin, Illia O., Zaika, Yevhen O., Brovarets, Volodymyr S., Doroshenko, Illia O., Grygorenko, Oleksandr O., Vashchenko, Bohdan V.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025
• Subjects: сультами; сульфаніламіди; дієни; дієнофіли; Дільс-Альдер; циклоприєднання
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/93
• Journal Title: Ukrainica Bioorganica Acta

This study explores the reactivity of five- and six-membered sultams as both dienes and dienophiles in Diels-Alder reactions. As dienes in [4+2] cycloaddition, vinyl sultam bearing an additional endocyclic C=C double bond reacted with highly electron-poor alkenes, namely with maleimide, revealing th...