Хроман-4-онові каркаси як платформа для пошуку протиракових та противірусних сполук-лідерів

• Date: 2025
• Author Affiliations: Oleksii S. Timokhin — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Enamine Ltd., Kyiv, Ukraine; Viktoriia S. Moskvina — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Olexandr V. Kucher — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine; Enamine Ltd., Kyiv, Ukraine; Kathy A. Keith — University of Alabama at Birmingham, Birmingham, Alabama, USA; Emma A. Harden — University of Alabama at Birmingham, Birmingham, Alabama, USA; Caroll B. Hartline — University of Alabama at Birmingham, Birmingham, Alabama, USA; Scott H. James — University of Alabama at Birmingham, Birmingham, Alabama, USA; Volodymyr S. Brovarets — V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine, Kyiv, Ukraine
• Keywords: keywords
• Main Authors: Timokhin, Oleksii S., Moskvina, Viktoriia S., Kucher, Olexandr V., Keith, Kathy A., Harden, Emma A., Hartline, Caroll B., James, Scott H., Brovarets, Volodymyr S.
• Format: Article
• Language: English
• Published: V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine 2025
• Subjects: оксигеновмісні гетероцикли; хроман-4-они; антипроліферативна активність; протиракова активність; противірусна активність
• Online Access: https://bioorganica.com.ua/index.php/journal/article/view/96
• Journal Title: Ukrainica Bioorganica Acta

Chroman-4-one derivatives, a class of oxygen-containing heterocycles commonly found in biologically active natural products, continue to attract significant attention for their potential in anticancer and antiviral drug discovery. In this study, a small library of eight chroman-4-one compounds was s...