ЕКСПРЕСІЯ ГЕНІВ РОДИНИ MRPS18 В ГЛІОМАХ

• Дата: 2023
• Автори: Kovalevska, L.M., Malysheva, T.A., Kalman, S.S., Rozumenko, A.V., Verbova, L.V., Rozumenko, V.D., Kashuba, E.V.
• Формат: Стаття
• Мова: English
• Опубліковано: PH Akademperiodyka 2023
• Теми: родина MRPS18; MRPS18-1; MRPS18-2; MRPS18-3; гліобластома; клітинні лінії гліом; експресія; біоінформатичний аналіз.
• Онлайн доступ: https://exp-oncology.com.ua/index.php/Exp/article/view/2021-3-6
• Назва журналу: Experimental Oncology

Summary. Aim: To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines. Materials and Methods: Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided. Results: The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest — for MRPS18-1 at mRNA level. Conclusions: The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines.