ІНДЕКС СПІВВІДНОШЕННЯ НЕЙТРОФІЛІВ ДО ЛІМФОЦИТІВ ЯК ПРОГНОСТИЧНИЙ МАРКЕР НЕМЕТАСТАТИЧНОГО НИРКОВО-КЛІТИННОГО РАКУ — ЧИ ЙОГО ВИЗНАЧЕННЯ МІСТИТЬ ДОДАТКОВУ ПРОГНОСТИЧНУ ІНФОРМАЦІЮ?

• Дата: 2023
• Автори: Rawoot, S., Punatar, C., Singh, V., Anand, A., Shah, B., Nagaonkar, S., Joshi, V.
• Формат: Стаття
• Мова: English
• Опубліковано: PH Akademperiodyka 2023
• Теми: співвідношення нейтрофілів до лімфоцитів; прогностичні фактори; нирково-клітинний рак.
• Онлайн доступ: https://exp-oncology.com.ua/index.php/Exp/article/view/2021-3-13
• Назва журналу: Experimental Oncology

Summary. Aim: To study the correlation of pre-operative neutrophil to lymphocyte ratio (NLR) with pathological stage, Fuhrman grade, sarcomatoid differentiation, tumor necrosis and lymph node positivity and its prognostic role in non-metastatic renal cell carcinoma (non-mRCC). Materials and Methods: This retro-prospective, observational study was done at a tertiary care center in Mumbai, India. All patients with non-mRCC from July 2015 to April 2018 were included. Patients with co-existing systemic infection, prior immunotherapy, and long-term steroids were excluded. NLR closest to surgery, but within one month prior to surgery was used. Patients were stratified as NLR ≥ 3.0 or < 3. NLR was correlated with known prognostic factors by Pearson’s correlation. Results: 113 patients, aged 18–81 years (83 males and 30 females) were included. 75% had clear cell RCC. 62% had stage 1 disease. 58% patients had Fuhrman Grade 2. 10 patients had lymph node metastasis, 6 had sarcomatoid differentiation, 40 had tumor necrosis. The NLR was < 3 in 72 patients. Statistically significant correlation between NLR and tumor stage (p = 0.0054) as well as NLR and tumor necrosis (p = 0.0128) was shown. Conclusions: NLR correlates significantly with higher T stage and tumor necrosis. NLR may be integrated with well-established prognostic markers to improve the accuracy of prognostic scores.