ЕФЕКТИВНІСТЬ ДИСПЕРГОВАНОГО ВОЛОКНИСТОГО ВУГЛЕЦЕВОГО СОРБЕНТУ ПРИ ЛІКУВАННІ ЗЛОЯКІСНИХ ФУНГОЇДНИХ РАН

• Datum: 2023
• Hauptverfasser: Sakhno, L.A., Babenko, L.P., Lazarenko, L.M., Korotych, V.G., Sarnatskaya, V.V., Snezhkova, E.A., Spivak, M.Ya., Nikolaev, V.G.
• Format: Artikel
• Sprache: English
• Veröffentlicht: PH Akademperiodyka 2023
• Schlagworte: адсорбційні перев’язувальні засоби; вуглецеві пов’язки; злоякісні фунгоїдні рани; хронічні рани; мікробіота рани; запах рани
• Online Zugang: https://exp-oncology.com.ua/index.php/Exp/article/view/2021-4-3
• Назва журналу: Experimental Oncology

Summary. Aim: To evaluate the influence of dispersed fibrous carbon sorbent (DFCS) on malignant fungating wounds (MFWs) in Guerin’s carcinoma-bearing rats with an assessment of wound bacterial microflora. Materials and Methods: The study was performed on female Wistar rats inoculated subcutaneously with Guerin T8 carcinoma into the upper interscapular region. On day 20, the tumors were infected by injecting the suspension of S. aureus 8325-4. After 24 h, gauze dressings were applied daily to the wounds in the control group and DFCS in the experimental one. The state of the wounds was assessed by visual control with photo monitoring, odor control on a verbal rating scale and microbiological analysis of qualitative and quantitative characteristics of wound microbiota. Results: On the 3rd day after the start of dressings, the number of S. aureus of 8325-4 strain was significantly higher in the wounds of rats in control group than experimental one (5.14 ± 0.27 vs 3.43 ± 0.33 lg CFU/ml). The total number of Staphylococci in the DFCS-treated wounds did not differ statistically from the number of S. aureus 8325-4 strain whereas in control ones were higher by an order of magnitude. On the 10th day the total number of Staphylococci and S. aureus 8325-4 in particular, remained consistently high in the wounds of the control rats, while was almost five orders of magnitude lower and represented mainly by S. aureus 8325-4 in the experimental ones. The total number of aerobic and optionally anaerobic microorganisms was significantly lower as well. A greater variety of microorganisms in the gauze-covered wounds, as well as an their increased number were accompanied by enhancement of the wound odor from “noticeable” to “strong”. There was an appearance of a “barely noticeable” odor in only one animal from the experimental group. Conclusion: The study has demonstrated the ability of DFCS to control substantially the bacterial microflora as well as malodor of MWFs in vivo. The results obtained can contribute to solving the problem of improving the quality of palliative care for patients with malignant and other chronic wounds.