NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer
Summary. The NF-kB1 gene belongs to the family of transcription factors that are involved in the regulation of a wide range of biological reactions. It has been established that NF-kB1 plays an important role in the regulation of immune responses, but more and more studies indicate...
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| Дата: | 2023 |
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| Мова: | English |
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PH Akademperiodyka
2023
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-1462023-10-11T16:43:48Z NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer Gaptulbarova, K.A. Tsyganov, M.M. Pevzner, A.M. Ibragimova, M.K. Litviakov, N.V. homologous recombination deficiency, marker, NF-kB1, personalized medicine homologous recombination deficiency, marker, NF-kB1, personalized medicine Summary. The NF-kB1 gene belongs to the family of transcription factors that are involved in the regulation of a wide range of biological reactions. It has been established that NF-kB1 plays an important role in the regulation of immune responses, but more and more studies indicate that this gene is involved in the processes of oncogenesis and DNA repair. The product of this gene regulates the expression of genes involved in the development and progression of cancer. In recent years, numerous studies have been aimed at elucidating the functional consequences of the activation of NF-kB1, as well as its signaling mechanisms. In this regard, NF-kB1 is an interesting therapeutic target for a possible personalized approach in the treatment of cancer. This article provides an overview of modern clinical studies of the NF-kB1 gene, which acts as a predictive and prognostic marker in the treatment of cancer. Summary. The NF-kB1 gene belongs to the family of transcription factors that are involved in the regulation of a wide range of biological reactions. It has been established that NF-kB1 plays an important role in the regulation of immune responses, but more and more studies indicate that this gene is involved in the processes of oncogenesis and DNA repair. The product of this gene regulates the expression of genes involved in the development and progression of cancer. In recent years, numerous studies have been aimed at elucidating the functional consequences of the activation of NF-kB1, as well as its signaling mechanisms. In this regard, NF-kB1 is an interesting therapeutic target for a possible personalized approach in the treatment of cancer. This article provides an overview of modern clinical studies of the NF-kB1 gene, which acts as a predictive and prognostic marker in the treatment of cancer. PH Akademperiodyka 2023-05-30 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-2 10.32471/exp-oncology.2312-8852.vol-42-no-4.15414 Experimental Oncology; Vol. 42 No. 4 (2020): Experimental Oncology; 263-269 Експериментальна онкологія; Том 42 № 4 (2020): Експериментальна онкологія; 263-269 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-4 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-2/2020-4-2 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
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Experimental Oncology |
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| datestamp_date |
2023-10-11T16:43:48Z |
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OJS |
| language |
English |
| topic |
homologous recombination deficiency marker NF-kB1 personalized medicine |
| spellingShingle |
homologous recombination deficiency marker NF-kB1 personalized medicine Gaptulbarova, K.A. Tsyganov, M.M. Pevzner, A.M. Ibragimova, M.K. Litviakov, N.V. NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| topic_facet |
homologous recombination deficiency marker NF-kB1 personalized medicine homologous recombination deficiency marker NF-kB1 personalized medicine |
| format |
Article |
| author |
Gaptulbarova, K.A. Tsyganov, M.M. Pevzner, A.M. Ibragimova, M.K. Litviakov, N.V. |
| author_facet |
Gaptulbarova, K.A. Tsyganov, M.M. Pevzner, A.M. Ibragimova, M.K. Litviakov, N.V. |
| author_sort |
Gaptulbarova, K.A. |
| title |
NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| title_short |
NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| title_full |
NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| title_fullStr |
NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| title_full_unstemmed |
NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| title_sort |
nf-kb as a potential prognostic marker and a candidate for targeted therapy of cancer |
| title_alt |
NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer |
| description |
Summary. The NF-kB1 gene belongs to the family of transcription factors that are involved in the regulation of a wide range of biological reactions. It has been established that NF-kB1 plays an important role in the regulation of immune responses, but more and more studies indicate that this gene is involved in the processes of oncogenesis and DNA repair. The product of this gene regulates the expression of genes involved in the development and progression of cancer. In recent years, numerous studies have been aimed at elucidating the functional consequences of the activation of NF-kB1, as well as its signaling mechanisms. In this regard, NF-kB1 is an interesting therapeutic target for a possible personalized approach in the treatment of cancer. This article provides an overview of modern clinical studies of the NF-kB1 gene, which acts as a predictive and prognostic marker in the treatment of cancer. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-2 |
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AT gaptulbarovaka nfkbasapotentialprognosticmarkerandacandidatefortargetedtherapyofcancer AT tsyganovmm nfkbasapotentialprognosticmarkerandacandidatefortargetedtherapyofcancer AT pevzneram nfkbasapotentialprognosticmarkerandacandidatefortargetedtherapyofcancer AT ibragimovamk nfkbasapotentialprognosticmarkerandacandidatefortargetedtherapyofcancer AT litviakovnv nfkbasapotentialprognosticmarkerandacandidatefortargetedtherapyofcancer |
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2025-07-17T12:15:49Z |
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2025-07-17T12:15:49Z |
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