Expression pattern of MRPS18 family genes in malignantly transformed b-cells
Summary. Aim: To compare expression patterns of proteins of a family of mitochondrial ribosomal protein S18 (MRPS18) in tumor cell lines of the B-cell origin. Materials and Methods: The study has been performed on different subsets of tonsil B-cells and tumor cell lines of the B-cell origin using qu...
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| Дата: | 2023 |
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| Мова: | English |
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PH Akademperiodyka
2023
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-1532023-10-11T16:43:48Z Expression pattern of MRPS18 family genes in malignantly transformed b-cells Expression pattern of MRPS18 family genes in malignantly transformed b-cells Kovalevska, L. Kashuba, E. B-cell lymphomas, Burkitt lymphoma., expression pattern, lymphoblastoid cell line, MRPS18 family, MRPS18-1, MRPS18-2, MRPS18-3 B-cell lymphomas, Burkitt lymphoma., expression pattern, lymphoblastoid cell line, MRPS18 family, MRPS18-1, MRPS18-2, MRPS18-3 Summary. Aim: To compare expression patterns of proteins of a family of mitochondrial ribosomal protein S18 (MRPS18) in tumor cell lines of the B-cell origin. Materials and Methods: The study has been performed on different subsets of tonsil B-cells and tumor cell lines of the B-cell origin using quantitative polymerase chain reaction analysis, western blot analysis, immunohistochemistry, bioinformatic analysis of the publicly available data bases on expression. Results: We have found that genes of the MRPS18 family (1–3) show different expression patterns in tumor cell lines of the B-cell origin. The highest levels of expression were shown for MRPS18-3, the lowest — for MRPS18-1. MRPS18-2 was expressed at the highest levels in germinal center cells, Burkitt lymphoma and Hodgkin lymphoma cell lines. At the protein levels, MRPS18-2 showed the highest expression in Burkitt lymphoma and B-cell precursor acute lymphoblastic leukemia cell lines. In lymphoblastoid cell lines, and in germinal center B-cells MRPS18-2 levels were somewhat lower, but higher than in memory and plasma B-cells. Conclusions: The differential expression pattern of the MRPS18 family proteins suggests that they play various roles in cellular processes. Summary. Aim: To compare expression patterns of proteins of a family of mitochondrial ribosomal protein S18 (MRPS18) in tumor cell lines of the B-cell origin. Materials and Methods: The study has been performed on different subsets of tonsil B-cells and tumor cell lines of the B-cell origin using quantitative polymerase chain reaction analysis, western blot analysis, immunohistochemistry, bioinformatic analysis of the publicly available data bases on expression. Results: We have found that genes of the MRPS18 family (1–3) show different expression patterns in tumor cell lines of the B-cell origin. The highest levels of expression were shown for MRPS18-3, the lowest — for MRPS18-1. MRPS18-2 was expressed at the highest levels in germinal center cells, Burkitt lymphoma and Hodgkin lymphoma cell lines. At the protein levels, MRPS18-2 showed the highest expression in Burkitt lymphoma and B-cell precursor acute lymphoblastic leukemia cell lines. In lymphoblastoid cell lines, and in germinal center B-cells MRPS18-2 levels were somewhat lower, but higher than in memory and plasma B-cells. Conclusions: The differential expression pattern of the MRPS18 family proteins suggests that they play various roles in cellular processes. PH Akademperiodyka 2023-05-30 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-8 10.32471/exp-oncology.2312-8852.vol-42-no-4.15366 Experimental Oncology; Vol. 42 No. 4 (2020): Experimental Oncology; 295-299 Експериментальна онкологія; Том 42 № 4 (2020): Експериментальна онкологія; 295-299 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-4 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-8/2020-4-8 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
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| datestamp_date |
2023-10-11T16:43:48Z |
| collection |
OJS |
| language |
English |
| topic |
B-cell lymphomas Burkitt lymphoma. expression pattern lymphoblastoid cell line MRPS18 family MRPS18-1 MRPS18-2 MRPS18-3 |
| spellingShingle |
B-cell lymphomas Burkitt lymphoma. expression pattern lymphoblastoid cell line MRPS18 family MRPS18-1 MRPS18-2 MRPS18-3 Kovalevska, L. Kashuba, E. Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| topic_facet |
B-cell lymphomas Burkitt lymphoma. expression pattern lymphoblastoid cell line MRPS18 family MRPS18-1 MRPS18-2 MRPS18-3 B-cell lymphomas Burkitt lymphoma. expression pattern lymphoblastoid cell line MRPS18 family MRPS18-1 MRPS18-2 MRPS18-3 |
| format |
Article |
| author |
Kovalevska, L. Kashuba, E. |
| author_facet |
Kovalevska, L. Kashuba, E. |
| author_sort |
Kovalevska, L. |
| title |
Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| title_short |
Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| title_full |
Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| title_fullStr |
Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| title_full_unstemmed |
Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| title_sort |
expression pattern of mrps18 family genes in malignantly transformed b-cells |
| title_alt |
Expression pattern of MRPS18 family genes in malignantly transformed b-cells |
| description |
Summary. Aim: To compare expression patterns of proteins of a family of mitochondrial ribosomal protein S18 (MRPS18) in tumor cell lines of the B-cell origin. Materials and Methods: The study has been performed on different subsets of tonsil B-cells and tumor cell lines of the B-cell origin using quantitative polymerase chain reaction analysis, western blot analysis, immunohistochemistry, bioinformatic analysis of the publicly available data bases on expression. Results: We have found that genes of the MRPS18 family (1–3) show different expression patterns in tumor cell lines of the B-cell origin. The highest levels of expression were shown for MRPS18-3, the lowest — for MRPS18-1. MRPS18-2 was expressed at the highest levels in germinal center cells, Burkitt lymphoma and Hodgkin lymphoma cell lines. At the protein levels, MRPS18-2 showed the highest expression in Burkitt lymphoma and B-cell precursor acute lymphoblastic leukemia cell lines. In lymphoblastoid cell lines, and in germinal center B-cells MRPS18-2 levels were somewhat lower, but higher than in memory and plasma B-cells. Conclusions: The differential expression pattern of the MRPS18 family proteins suggests that they play various roles in cellular processes. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-8 |
| work_keys_str_mv |
AT kovalevskal expressionpatternofmrps18familygenesinmalignantlytransformedbcells AT kashubae expressionpatternofmrps18familygenesinmalignantlytransformedbcells |
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2025-07-17T12:15:53Z |
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2025-07-17T12:15:53Z |
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