Molecular phenotype of high-grade endometrioid carcinoma of the endometrium
Summary. Background: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with t...
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| Дата: | 2023 |
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| Мова: | English |
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PH Akademperiodyka
2023
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| Назва журналу: | Experimental Oncology |
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Experimental Oncology| id |
oai:ojs2.ex.aqua-time.com.ua:article-156 |
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Experimental Oncology |
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2023-10-11T16:43:48Z |
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English |
| topic |
endometrioid carcinoma of the endometrium expression of biomarkers informative relevance molecular phenotype |
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endometrioid carcinoma of the endometrium expression of biomarkers informative relevance molecular phenotype Buchynska, L.G. Glushchenko, N.M. Nesina, I.P. Brieieva, O.V. Iurchenko, N.P. Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| topic_facet |
endometrioid carcinoma of the endometrium expression of biomarkers informative relevance molecular phenotype endometrioid carcinoma of the endometrium expression of biomarkers informative relevance molecular phenotype |
| format |
Article |
| author |
Buchynska, L.G. Glushchenko, N.M. Nesina, I.P. Brieieva, O.V. Iurchenko, N.P. |
| author_facet |
Buchynska, L.G. Glushchenko, N.M. Nesina, I.P. Brieieva, O.V. Iurchenko, N.P. |
| author_sort |
Buchynska, L.G. |
| title |
Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| title_short |
Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| title_full |
Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| title_fullStr |
Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| title_full_unstemmed |
Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| title_sort |
molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| title_alt |
Molecular phenotype of high-grade endometrioid carcinoma of the endometrium |
| description |
Summary. Background: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with the aggressive phenotype of endometrioid carcinomas is indisputably urgent. Aim: To study molecular-biological features of endometrioid carcinoma of the endometrium (ECE) and to identify the molecular subtype of tumors with high potential of malignancy. Materials and Methods: Surgical specimens of 127 patients with EC, stages I–II, aged 36–72 (the average age — 59.3 ± 3.2) were studied using morphological and immunohistochemical methods. The multivariant analysis with the Kullback’s informative measure and PanelomiX were used to estimate the significance of the expression of specific biomarkers. Results: The expression of a complex of multifunctional markers was evaluated in ECE cells of different malignancy stage: p53, FOXP3, p21WAF1/CIP1, р16INK4a, E2F1, cyclins Е and D1, Her2/neu, с-Myc, Е-cadherin, β-catenin, vimentin, CD44, CD24. A triad of biomarkers with threshold expression levels was determined (р53 > 45%; FOXP3 < 14%; с-Myc > 10%). The high expression of oncogene c-Myc and oncosuppressor p53 along with the low level of FOXP3 in tumor cells of ECE was associated with high proliferative potential, low differentiation grade, and deep invasion of a tumor into the myometrium. Conclusions: The molecular phenotype of ECE, most informative in terms of specificity and sensitivity (95%) — р53highFOXP3lowc-Mychigh, was first characterized, which would help identify a high-grade subtype of this cancer form. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-11 |
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AT buchynskalg molecularphenotypeofhighgradeendometrioidcarcinomaoftheendometrium AT glushchenkonm molecularphenotypeofhighgradeendometrioidcarcinomaoftheendometrium AT nesinaip molecularphenotypeofhighgradeendometrioidcarcinomaoftheendometrium AT brieievaov molecularphenotypeofhighgradeendometrioidcarcinomaoftheendometrium AT iurchenkonp molecularphenotypeofhighgradeendometrioidcarcinomaoftheendometrium |
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2025-07-17T12:15:55Z |
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2025-07-17T12:15:55Z |
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1850411032625807360 |
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oai:ojs2.ex.aqua-time.com.ua:article-1562023-10-11T16:43:48Z Molecular phenotype of high-grade endometrioid carcinoma of the endometrium Molecular phenotype of high-grade endometrioid carcinoma of the endometrium Buchynska, L.G. Glushchenko, N.M. Nesina, I.P. Brieieva, O.V. Iurchenko, N.P. endometrioid carcinoma of the endometrium, expression of biomarkers, informative relevance, molecular phenotype endometrioid carcinoma of the endometrium, expression of biomarkers, informative relevance, molecular phenotype Summary. Background: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with the aggressive phenotype of endometrioid carcinomas is indisputably urgent. Aim: To study molecular-biological features of endometrioid carcinoma of the endometrium (ECE) and to identify the molecular subtype of tumors with high potential of malignancy. Materials and Methods: Surgical specimens of 127 patients with EC, stages I–II, aged 36–72 (the average age — 59.3 ± 3.2) were studied using morphological and immunohistochemical methods. The multivariant analysis with the Kullback’s informative measure and PanelomiX were used to estimate the significance of the expression of specific biomarkers. Results: The expression of a complex of multifunctional markers was evaluated in ECE cells of different malignancy stage: p53, FOXP3, p21WAF1/CIP1, р16INK4a, E2F1, cyclins Е and D1, Her2/neu, с-Myc, Е-cadherin, β-catenin, vimentin, CD44, CD24. A triad of biomarkers with threshold expression levels was determined (р53 > 45%; FOXP3 < 14%; с-Myc > 10%). The high expression of oncogene c-Myc and oncosuppressor p53 along with the low level of FOXP3 in tumor cells of ECE was associated with high proliferative potential, low differentiation grade, and deep invasion of a tumor into the myometrium. Conclusions: The molecular phenotype of ECE, most informative in terms of specificity and sensitivity (95%) — р53highFOXP3lowc-Mychigh, was first characterized, which would help identify a high-grade subtype of this cancer form. Summary. Background: Prognosis of the course of tumor progression is one of urgent problems of clinical oncology. A relevant specificity of endometrial cancer is its clinical polymorphism within the same histological type of the disease. The search for molecular-biological features associated with the aggressive phenotype of endometrioid carcinomas is indisputably urgent. Aim: To study molecular-biological features of endometrioid carcinoma of the endometrium (ECE) and to identify the molecular subtype of tumors with high potential of malignancy. Materials and Methods: Surgical specimens of 127 patients with EC, stages I–II, aged 36–72 (the average age — 59.3 ± 3.2) were studied using morphological and immunohistochemical methods. The multivariant analysis with the Kullback’s informative measure and PanelomiX were used to estimate the significance of the expression of specific biomarkers. Results: The expression of a complex of multifunctional markers was evaluated in ECE cells of different malignancy stage: p53, FOXP3, p21WAF1/CIP1, р16INK4a, E2F1, cyclins Е and D1, Her2/neu, с-Myc, Е-cadherin, β-catenin, vimentin, CD44, CD24. A triad of biomarkers with threshold expression levels was determined (р53 > 45%; FOXP3 < 14%; с-Myc > 10%). The high expression of oncogene c-Myc and oncosuppressor p53 along with the low level of FOXP3 in tumor cells of ECE was associated with high proliferative potential, low differentiation grade, and deep invasion of a tumor into the myometrium. Conclusions: The molecular phenotype of ECE, most informative in terms of specificity and sensitivity (95%) — р53highFOXP3lowc-Mychigh, was first characterized, which would help identify a high-grade subtype of this cancer form. PH Akademperiodyka 2023-05-30 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-11 10.32471/exp-oncology.2312-8852.vol-42-no-4.15450 Experimental Oncology; Vol. 42 No. 4 (2020): Experimental Oncology; 300-305 Експериментальна онкологія; Том 42 № 4 (2020): Експериментальна онкологія; 300-305 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-4 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-4-11/2020-4-11 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |