Histological differential diagnostics of renal oncocytoma
Summary. Background: The morbidity rate of kidney cancer has been increasing. Management of patients and their prognosis depend on the specific histological type of tumor. Unfortunately, different renal tumors can have similar histological features, making differential diagnostics challenging. Among...
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| Date: | 2023 |
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PH Akademperiodyka
2023
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Experimental Oncology |
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2023-10-11T16:43:26Z |
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chromophobe renal cell carcinoma differential diagnostics kidney cancer. renal oncocytoma renal tumors with eosinophilic appearance |
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chromophobe renal cell carcinoma differential diagnostics kidney cancer. renal oncocytoma renal tumors with eosinophilic appearance Baranovska, V.V. Romanenko, A.M. Zakhartseva, L.M. Histological differential diagnostics of renal oncocytoma |
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chromophobe renal cell carcinoma differential diagnostics kidney cancer. renal oncocytoma renal tumors with eosinophilic appearance chromophobe renal cell carcinoma differential diagnostics kidney cancer. renal oncocytoma renal tumors with eosinophilic appearance |
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Article |
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Baranovska, V.V. Romanenko, A.M. Zakhartseva, L.M. |
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Baranovska, V.V. Romanenko, A.M. Zakhartseva, L.M. |
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Baranovska, V.V. |
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Histological differential diagnostics of renal oncocytoma |
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Histological differential diagnostics of renal oncocytoma |
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Histological differential diagnostics of renal oncocytoma |
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Histological differential diagnostics of renal oncocytoma |
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Histological differential diagnostics of renal oncocytoma |
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histological differential diagnostics of renal oncocytoma |
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Histological differential diagnostics of renal oncocytoma |
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Summary. Background: The morbidity rate of kidney cancer has been increasing. Management of patients and their prognosis depend on the specific histological type of tumor. Unfortunately, different renal tumors can have similar histological features, making differential diagnostics challenging. Among the most challenging tasks is differential diagnosis of renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC). Aim: To analyze different histological features of renal oncocytomas and specify their pathognomonic characteristics that may be advantageous for the confirmation of the diagnosis. Materials and Methods: The medical records and histopathological reports of 197 patients with diagnosis of either RO or ChRCC were analyzed. 37 histological parameters were then evaluated and their prevalence in RO or ChRCC was compared by performing a contingency table analysis. Odds ratio was also calculated. Results: The most common growth patterns of ROs were solid (53%), nested (47%), cystic (29%), and alveolar (28%). A combination of two or more growth patterns was seen in 82% of cases mostly composing of nested, cystic, alveolar or solid structures. Most tumors exhibited granular inclusions (70%) and dense cytoplasm (58%). Conclusion: With more than 95% confidence, the nested pattern, myxoid stroma, granular cytoplasm and round nuclei are likely indicative of RO, whereas the varying nuclear size, raisinoid nuclei and reticular cytoplasm indicate higher likelihood of ChRCC. Therefore, these features should be analyzed for RO confirmation. |
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PH Akademperiodyka |
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2023 |
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https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-8 |
| work_keys_str_mv |
AT baranovskavv histologicaldifferentialdiagnosticsofrenaloncocytoma AT romanenkoam histologicaldifferentialdiagnosticsofrenaloncocytoma AT zakhartsevalm histologicaldifferentialdiagnosticsofrenaloncocytoma |
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2025-07-17T12:16:06Z |
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2025-07-17T12:16:06Z |
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oai:ojs2.ex.aqua-time.com.ua:article-1712023-10-11T16:43:26Z Histological differential diagnostics of renal oncocytoma Histological differential diagnostics of renal oncocytoma Baranovska, V.V. Romanenko, A.M. Zakhartseva, L.M. chromophobe renal cell carcinoma, differential diagnostics, kidney cancer., renal oncocytoma, renal tumors with eosinophilic appearance chromophobe renal cell carcinoma, differential diagnostics, kidney cancer., renal oncocytoma, renal tumors with eosinophilic appearance Summary. Background: The morbidity rate of kidney cancer has been increasing. Management of patients and their prognosis depend on the specific histological type of tumor. Unfortunately, different renal tumors can have similar histological features, making differential diagnostics challenging. Among the most challenging tasks is differential diagnosis of renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC). Aim: To analyze different histological features of renal oncocytomas and specify their pathognomonic characteristics that may be advantageous for the confirmation of the diagnosis. Materials and Methods: The medical records and histopathological reports of 197 patients with diagnosis of either RO or ChRCC were analyzed. 37 histological parameters were then evaluated and their prevalence in RO or ChRCC was compared by performing a contingency table analysis. Odds ratio was also calculated. Results: The most common growth patterns of ROs were solid (53%), nested (47%), cystic (29%), and alveolar (28%). A combination of two or more growth patterns was seen in 82% of cases mostly composing of nested, cystic, alveolar or solid structures. Most tumors exhibited granular inclusions (70%) and dense cytoplasm (58%). Conclusion: With more than 95% confidence, the nested pattern, myxoid stroma, granular cytoplasm and round nuclei are likely indicative of RO, whereas the varying nuclear size, raisinoid nuclei and reticular cytoplasm indicate higher likelihood of ChRCC. Therefore, these features should be analyzed for RO confirmation. Summary. Background: The morbidity rate of kidney cancer has been increasing. Management of patients and their prognosis depend on the specific histological type of tumor. Unfortunately, different renal tumors can have similar histological features, making differential diagnostics challenging. Among the most challenging tasks is differential diagnosis of renal oncocytoma (RO) and chromophobe renal cell carcinoma (ChRCC). Aim: To analyze different histological features of renal oncocytomas and specify their pathognomonic characteristics that may be advantageous for the confirmation of the diagnosis. Materials and Methods: The medical records and histopathological reports of 197 patients with diagnosis of either RO or ChRCC were analyzed. 37 histological parameters were then evaluated and their prevalence in RO or ChRCC was compared by performing a contingency table analysis. Odds ratio was also calculated. Results: The most common growth patterns of ROs were solid (53%), nested (47%), cystic (29%), and alveolar (28%). A combination of two or more growth patterns was seen in 82% of cases mostly composing of nested, cystic, alveolar or solid structures. Most tumors exhibited granular inclusions (70%) and dense cytoplasm (58%). Conclusion: With more than 95% confidence, the nested pattern, myxoid stroma, granular cytoplasm and round nuclei are likely indicative of RO, whereas the varying nuclear size, raisinoid nuclei and reticular cytoplasm indicate higher likelihood of ChRCC. Therefore, these features should be analyzed for RO confirmation. PH Akademperiodyka 2023-05-31 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-8 10.32471/exp-oncology.2312-8852.vol-42-no-3.14968 Experimental Oncology; Vol. 42 No. 3 (2020): Experimental Oncology; 233-237 Експериментальна онкологія; Том 42 № 3 (2020): Експериментальна онкологія; 233-237 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-8/2020-3-8 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |