Tumor microenvironment changes tumor cell sensitivity to action of energy metabolism modifiers

• Date: 2023
• Main Authors: Pyaskovskaya, O.N., Kolesnik, D.L., Prokhorova, I.V., Burlaka, A.P., Gorbach, O.I., Solyanik, G.I.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: metformin; sodium dichloroacetate; tumor growth and metastasis
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-9
• Journal Title: Experimental Oncology

Summary. Background: Taking into account differences in the bioenergetics between malignant and normal cells a search of antitumor drugs among the modifiers of tumor metabolism has a reasonable excuse. Earlier it was found that the cytotoxic/cytostatic action of sodium dichloroacetate (DCA) against...