Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas
Summary. Aim: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79&...
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| Дата: | 2023 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
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PH Akademperiodyka
2023
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| Онлайн доступ: | https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-11 |
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| Назва журналу: | Experimental Oncology |
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Experimental Oncology| _version_ | 1856543494348210176 |
|---|---|
| author | Dumanskiy, Y.V. Stoliarova, O.Y. Syniachenko, О.V. Aliev, R.F. Iermolaeva, М.V. Sokrut, О.P. |
| author_facet | Dumanskiy, Y.V. Stoliarova, O.Y. Syniachenko, О.V. Aliev, R.F. Iermolaeva, М.V. Sokrut, О.P. |
| author_sort | Dumanskiy, Y.V. |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2023-10-11T16:43:26Z |
| description | Summary. Aim: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1. Serum levels of purine metabolism products (uric acid, oxypurinol, adenine, guanine, xanthine, hypoxanthine) were measured and activities of xanthine oxidase, xanthine deaminase, adenosine deaminase and 5-nucleotidase were analyzed. Results: Purine metabolism disorders are observed in all GAC and 91% of PAC patients; among other things, hyperuricemia is observed in ¾ and ½ of cases, respectively; moreover, the nature of changes is more pronounced in gastric cancer and, in both groups of patients, these indices reflect the disease course severity, are associated with the neoplastic process localization, have a predictive value, trigger the development of metastases. Conclusion: Сhanges in purine metabolism are involved in the pathogenetic patterns of GAC and PAC, reflect the course of the tumor process, are associated with tumor localization and have prognostic significance. |
| first_indexed | 2025-07-17T12:16:07Z |
| format | Article |
| id | oai:ojs2.ex.aqua-time.com.ua:article-174 |
| institution | Experimental Oncology |
| language | English |
| last_indexed | 2025-07-17T12:16:07Z |
| publishDate | 2023 |
| publisher | PH Akademperiodyka |
| record_format | ojs |
| spelling | oai:ojs2.ex.aqua-time.com.ua:article-1742023-10-11T16:43:26Z Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas Dumanskiy, Y.V. Stoliarova, O.Y. Syniachenko, О.V. Aliev, R.F. Iermolaeva, М.V. Sokrut, О.P. adenocarcinoma, cancer, lung, metabolism, purines, stomach adenocarcinoma, cancer, lung, metabolism, purines, stomach Summary. Aim: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1. Serum levels of purine metabolism products (uric acid, oxypurinol, adenine, guanine, xanthine, hypoxanthine) were measured and activities of xanthine oxidase, xanthine deaminase, adenosine deaminase and 5-nucleotidase were analyzed. Results: Purine metabolism disorders are observed in all GAC and 91% of PAC patients; among other things, hyperuricemia is observed in ¾ and ½ of cases, respectively; moreover, the nature of changes is more pronounced in gastric cancer and, in both groups of patients, these indices reflect the disease course severity, are associated with the neoplastic process localization, have a predictive value, trigger the development of metastases. Conclusion: Сhanges in purine metabolism are involved in the pathogenetic patterns of GAC and PAC, reflect the course of the tumor process, are associated with tumor localization and have prognostic significance. Summary. Aim: To study the state of purine metabolism in gastric (GAC) and pulmonary (PAC) adenocarcinomas and to assess its clinical and pathogenetic significance. Patients and Methods: One hundred and six male patients were examined, among whom were 63 subjects aged 34 to 79 suffering from GAC, and 43 subjects aged 24 to 76 suffering from PAC. In GAC, the ratio of the pyloric, corporeal and antral localization of the tumor and variant of overall gastric lesion accounted to 24:5:1:1; and that of the central and peripheral PAC was 2:1. Serum levels of purine metabolism products (uric acid, oxypurinol, adenine, guanine, xanthine, hypoxanthine) were measured and activities of xanthine oxidase, xanthine deaminase, adenosine deaminase and 5-nucleotidase were analyzed. Results: Purine metabolism disorders are observed in all GAC and 91% of PAC patients; among other things, hyperuricemia is observed in ¾ and ½ of cases, respectively; moreover, the nature of changes is more pronounced in gastric cancer and, in both groups of patients, these indices reflect the disease course severity, are associated with the neoplastic process localization, have a predictive value, trigger the development of metastases. Conclusion: Сhanges in purine metabolism are involved in the pathogenetic patterns of GAC and PAC, reflect the course of the tumor process, are associated with tumor localization and have prognostic significance. PH Akademperiodyka 2023-05-31 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-11 10.32471/exp-oncology.2312-8852.vol-42-no-3.15068 Experimental Oncology; Vol. 42 No. 3 (2020): Experimental Oncology; 220-223 Експериментальна онкологія; Том 42 № 3 (2020): Експериментальна онкологія; 220-223 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-11/2020-3-11 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | adenocarcinoma cancer lung metabolism purines stomach Dumanskiy, Y.V. Stoliarova, O.Y. Syniachenko, О.V. Aliev, R.F. Iermolaeva, М.V. Sokrut, О.P. Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title | Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title_alt | Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title_full | Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title_fullStr | Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title_full_unstemmed | Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title_short | Comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| title_sort | comparative evaluation of purine dysmetabolism in gastric and pulmonary adenocarcinomas |
| topic | adenocarcinoma cancer lung metabolism purines stomach |
| topic_facet | adenocarcinoma cancer lung metabolism purines stomach adenocarcinoma cancer lung metabolism purines stomach |
| url | https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-11 |
| work_keys_str_mv | AT dumanskiyyv comparativeevaluationofpurinedysmetabolismingastricandpulmonaryadenocarcinomas AT stoliarovaoy comparativeevaluationofpurinedysmetabolismingastricandpulmonaryadenocarcinomas AT syniachenkoov comparativeevaluationofpurinedysmetabolismingastricandpulmonaryadenocarcinomas AT alievrf comparativeevaluationofpurinedysmetabolismingastricandpulmonaryadenocarcinomas AT iermolaevamv comparativeevaluationofpurinedysmetabolismingastricandpulmonaryadenocarcinomas AT sokrutop comparativeevaluationofpurinedysmetabolismingastricandpulmonaryadenocarcinomas |