Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma
Summary. Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by John Cunningham virus (JCV). We present a case report of patient with non-Hodgkin follicular lymphoma, who developed PML after hematopoietic stem cell tra...
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| Datum: | 2023 |
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PH Akademperiodyka
2023
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Experimental Oncology| _version_ | 1856543498430316544 |
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| author | Trociukas, I. Zirnis, A.E. Beļajeva, L. Rivkina, A. Lejniece, S. |
| author_facet | Trociukas, I. Zirnis, A.E. Beļajeva, L. Rivkina, A. Lejniece, S. |
| author_sort | Trociukas, I. |
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| datestamp_date | 2023-10-11T16:43:26Z |
| description | Summary. Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by John Cunningham virus (JCV). We present a case report of patient with non-Hodgkin follicular lymphoma, who developed PML after hematopoietic stem cell transplantation and rituximab-bendamustine therapy. JCV DNA was proven both in peripheral blood and cerebrospinal fluid. Patient with 4 years history of follicular lymphoma presented with progressing weakness in the right arm and leg and postural instability. Magnetic resonance imaging scans showed bilateral hyperintense lesions in the cerebellum and centrum semiovale consistent with findings in PML. JCV DNA was detected in patient peripheral blood and cerebrospinal fluid by real time polymerase chain reaction assay in CERBA laboratory (France). Human herpes simplex 6 and 7 DNA were also detected in peripheral blood by PCR. Patients condition rapidly deteriorated with exitus letalis after 3 months and 2 weeks from onset of symptoms. This case draws attention to risk for developing PML in patients with long-standing hematological malignancies. |
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| id | oai:ojs2.ex.aqua-time.com.ua:article-182 |
| institution | Experimental Oncology |
| language | English |
| last_indexed | 2025-07-17T12:16:13Z |
| publishDate | 2023 |
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| spelling | oai:ojs2.ex.aqua-time.com.ua:article-1822023-10-11T16:43:26Z Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma Trociukas, I. Zirnis, A.E. Beļajeva, L. Rivkina, A. Lejniece, S. follicular lymphoma, hematopoietic stem cell transplantation, JC polyomavirus, progressive multifocal leukoencephalopathy, rituximab-bendamustine follicular lymphoma, hematopoietic stem cell transplantation, JC polyomavirus, progressive multifocal leukoencephalopathy, rituximab-bendamustine Summary. Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by John Cunningham virus (JCV). We present a case report of patient with non-Hodgkin follicular lymphoma, who developed PML after hematopoietic stem cell transplantation and rituximab-bendamustine therapy. JCV DNA was proven both in peripheral blood and cerebrospinal fluid. Patient with 4 years history of follicular lymphoma presented with progressing weakness in the right arm and leg and postural instability. Magnetic resonance imaging scans showed bilateral hyperintense lesions in the cerebellum and centrum semiovale consistent with findings in PML. JCV DNA was detected in patient peripheral blood and cerebrospinal fluid by real time polymerase chain reaction assay in CERBA laboratory (France). Human herpes simplex 6 and 7 DNA were also detected in peripheral blood by PCR. Patients condition rapidly deteriorated with exitus letalis after 3 months and 2 weeks from onset of symptoms. This case draws attention to risk for developing PML in patients with long-standing hematological malignancies. Summary. Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by John Cunningham virus (JCV). We present a case report of patient with non-Hodgkin follicular lymphoma, who developed PML after hematopoietic stem cell transplantation and rituximab-bendamustine therapy. JCV DNA was proven both in peripheral blood and cerebrospinal fluid. Patient with 4 years history of follicular lymphoma presented with progressing weakness in the right arm and leg and postural instability. Magnetic resonance imaging scans showed bilateral hyperintense lesions in the cerebellum and centrum semiovale consistent with findings in PML. JCV DNA was detected in patient peripheral blood and cerebrospinal fluid by real time polymerase chain reaction assay in CERBA laboratory (France). Human herpes simplex 6 and 7 DNA were also detected in peripheral blood by PCR. Patients condition rapidly deteriorated with exitus letalis after 3 months and 2 weeks from onset of symptoms. This case draws attention to risk for developing PML in patients with long-standing hematological malignancies. PH Akademperiodyka 2023-05-31 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-19 10.32471/exp-oncology.2312-8852.vol-42-no-3.15198 Experimental Oncology; Vol. 42 No. 3 (2020): Experimental Oncology; 238-241 Експериментальна онкологія; Том 42 № 3 (2020): Експериментальна онкологія; 238-241 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-42-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-19/2020-3-19 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | follicular lymphoma hematopoietic stem cell transplantation JC polyomavirus progressive multifocal leukoencephalopathy rituximab-bendamustine Trociukas, I. Zirnis, A.E. Beļajeva, L. Rivkina, A. Lejniece, S. Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title | Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title_alt | Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title_full | Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title_fullStr | Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title_full_unstemmed | Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title_short | Progressive multifocal encephalopathy in a patient with non-Hodgkin follicular lymphoma |
| title_sort | progressive multifocal encephalopathy in a patient with non-hodgkin follicular lymphoma |
| topic | follicular lymphoma hematopoietic stem cell transplantation JC polyomavirus progressive multifocal leukoencephalopathy rituximab-bendamustine |
| topic_facet | follicular lymphoma hematopoietic stem cell transplantation JC polyomavirus progressive multifocal leukoencephalopathy rituximab-bendamustine follicular lymphoma hematopoietic stem cell transplantation JC polyomavirus progressive multifocal leukoencephalopathy rituximab-bendamustine |
| url | https://exp-oncology.com.ua/index.php/Exp/article/view/2020-3-19 |
| work_keys_str_mv | AT trociukasi progressivemultifocalencephalopathyinapatientwithnonhodgkinfollicularlymphoma AT zirnisae progressivemultifocalencephalopathyinapatientwithnonhodgkinfollicularlymphoma AT belajeval progressivemultifocalencephalopathyinapatientwithnonhodgkinfollicularlymphoma AT rivkinaa progressivemultifocalencephalopathyinapatientwithnonhodgkinfollicularlymphoma AT lejnieces progressivemultifocalencephalopathyinapatientwithnonhodgkinfollicularlymphoma |