Inhibition of USP1, a new partner of Bcr-Abl, results in decrease of Bcr-Abl level in K562 cells

• Date: 2023
• Main Authors: Antonenko, S.V., Telegeev, G.D.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: Bcr-Abl oncoprotein; chronic myeloid leukemia; K562 cells; ML323 inhibitor; USP1 protein
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-10
• Journal Title: Experimental Oncology

Summary. Aim: To analyze interaction of ubiquitin specific peptidase 1 (USP1) with Bcr-Abl and to assess the relation between USP1 functional activity and Bcr-Abl expression in K562 chronic myeloid leukemia cells. Materials and Methods: The interaction between USP1 and Bcr-Abl in K562&n...