Conjugation of new DNA vaccine with polyethylenimine induces cellular immune response and tumor regression in neuroblastoma mouse model

• Date: 2023
• Main Authors: Stegantseva, M.V., Shinkevich, V.A., Tumar, E.M., Meleshko, A.N.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: DNA vaccine; neuroblastoma; polyethylenimine; tyrosine hydroxylase
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-2-11
• Journal Title: Experimental Oncology

Summary. Aim: To estimate immunogenicity and antitumor effect of new DNA vaccine against neuroblastoma using tyrosine hydroxylase as an antigen and linear polyethylenimine (PEI) 20 kDa as a synthetic DNA carrier in syngeneic mouse tumor model. Materials and Methods: DNA vaccine was made by...