Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia

• Дата: 2023
• Автори: Gong, Y., Wu, J., Yang, R., Zhang, L., Ma, Z.
• Формат: Стаття
• Мова: Англійська
• Опубліковано: PH Akademperiodyka 2023
• Теми: acute lymphoblastic leukemia; autophagy; ciclopirox olamine; ferritin; rapamycin
• Онлайн доступ: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-3
• Назва журналу: Experimental Oncology

Summary. Elevated mammalian target of rapamycin (mTOR) signaling has been reported to correlate with poor prognosis in acute lymphoblastic leukemia (ALL) patients. Rapamycin, an mTOR kinase inhibitor, and also a potent autophagy inducer, could not only effectively reverse glucocorticoid resistance,...