Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia

• Date: 2023
• Main Authors: Gong, Y., Wu, J., Yang, R., Zhang, L., Ma, Z.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: acute lymphoblastic leukemia; autophagy; ciclopirox olamine; ferritin; rapamycin
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-3
• Journal Title: Experimental Oncology

Summary. Elevated mammalian target of rapamycin (mTOR) signaling has been reported to correlate with poor prognosis in acute lymphoblastic leukemia (ALL) patients. Rapamycin, an mTOR kinase inhibitor, and also a potent autophagy inducer, could not only effectively reverse glucocorticoid resistance,...