MYC copy number and mRNA expression in chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chornobyl NPP accident

• Datum: 2023
• Hauptverfasser: Bilous, N., Abramenko, I., Chumak, A., Dyagil, I., Martina, Z.
• Format: Artikel
• Sprache: English
• Veröffentlicht: PH Akademperiodyka 2023
• Schlagworte: 8q24.1; chronic lymphocytic leukemia; gene copy number; MYC gene
• Online Zugang: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-9
• Назва журналу: Experimental Oncology

Summary. Some clinical and biological features indicating an unfavorable course of the disease were found in ionizing radiation (IR) — related chronic lymphocytic leukemia (CLL) patients. The MYC proto-oncogene is considered to contribute to CLL pathogenesis. Increased MYC copy number is as...