Metformin enhances cytotoxic action of dichloroacetate against Lewis lung carcinoma cells in vitro

• Date: 2023
• Main Authors: Kolesnik, D.L., Pyaskovskaya, O.N., Gorbach, O., Solyanik, G.I.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: Lewis lung carcinoma; metformin; sodium dichloroacetate
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-11
• Journal Title: Experimental Oncology

Summary. Tumor cell metabolism is considered one of the hallmarks of cancer. This concept is exploited in the development of new ways of anticancer therapy based on the use of substances capable of changing drastically bioenergetic metabolism of tumor cells. Among them, sodium dichloroace­tate (DCA)...