High expression of GLI1 is associated with better survival in advanced SCLC

• Date: 2023
• Main Authors: Kozirovskis, V., Zandberga, E., Magone, M., Purkalne, G., Linē, A., Vikmanis, U.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: GLI1; prognosis; small cell lung cancer; Sonic hedgehog pathway; survival
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2020-1-13
• Journal Title: Experimental Oncology

Summary. Aim: Aberrant Sonic hedgehog (Shh) pathway signaling has been described in small cell lung cancer (SCLC), as well discrepancies, when analyzing expression of pathway components in SCLC cell lines vs tumor biopsies. Shh key component GLI1 was evaluated in advanced SCLC and data corr...