Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB4 leukemia cells via down-regulation of BIRC5 expression

• Date: 2023
• Main Authors: Dehghan Nayeri, M.J., Mahdavi, M., Fazeli, H., Hosseinpour Feizi, M.A.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: apoptosis; cell cycle; NB4 cell line; spiroaminopyrimidine
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-5
• Journal Title: Experimental Oncology

Summary. Aim: It has been reported that spiroaminopyrimidine derivatives inhibited the growth and proliferation of various cancer cell lines. In the present study, we evaluated cytotoxic and apoptosis-inducing effects of 2,4-diamino-1,3-diazaspiro[5.5]-9-tert-butyl-2, 4-diene-5-carbonitril (9-tBAP)...