Macrophages — a perspective target for antineoplastic immunotherapy
Summary. The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (densi...
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| Дата: | 2023 |
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| Автори: | , , |
| Формат: | Стаття |
| Мова: | English |
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PH Akademperiodyka
2023
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-2192023-10-11T16:42:06Z Macrophages — a perspective target for antineoplastic immunotherapy Macrophages — a perspective target for antineoplastic immunotherapy Karaman, О.М. Ivanchenko, A.V. Chekhun, V.F. M1/M2 macrophages, malignant tumors, plasticity, polarization M1/M2 macrophages, malignant tumors, plasticity, polarization Summary. The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity. Summary. The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity. PH Akademperiodyka 2023-06-02 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-9 10.32471/exp-oncology.2312-8852.vol-41-no-4.13698 Experimental Oncology; Vol. 41 No. 4 (2019): Experimental Oncology; 282-290 Експериментальна онкологія; Том 41 № 4 (2019): Експериментальна онкологія; 282-290 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-4 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-9/2019-4-9 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2023-10-11T16:42:06Z |
| collection |
OJS |
| language |
English |
| topic |
M1/M2 macrophages malignant tumors plasticity polarization |
| spellingShingle |
M1/M2 macrophages malignant tumors plasticity polarization Karaman, О.М. Ivanchenko, A.V. Chekhun, V.F. Macrophages — a perspective target for antineoplastic immunotherapy |
| topic_facet |
M1/M2 macrophages malignant tumors plasticity polarization M1/M2 macrophages malignant tumors plasticity polarization |
| format |
Article |
| author |
Karaman, О.М. Ivanchenko, A.V. Chekhun, V.F. |
| author_facet |
Karaman, О.М. Ivanchenko, A.V. Chekhun, V.F. |
| author_sort |
Karaman, О.М. |
| title |
Macrophages — a perspective target for antineoplastic immunotherapy |
| title_short |
Macrophages — a perspective target for antineoplastic immunotherapy |
| title_full |
Macrophages — a perspective target for antineoplastic immunotherapy |
| title_fullStr |
Macrophages — a perspective target for antineoplastic immunotherapy |
| title_full_unstemmed |
Macrophages — a perspective target for antineoplastic immunotherapy |
| title_sort |
macrophages — a perspective target for antineoplastic immunotherapy |
| title_alt |
Macrophages — a perspective target for antineoplastic immunotherapy |
| description |
Summary. The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-4-9 |
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AT karamanom macrophagesaperspectivetargetforantineoplasticimmunotherapy AT ivanchenkoav macrophagesaperspectivetargetforantineoplasticimmunotherapy AT chekhunvf macrophagesaperspectivetargetforantineoplasticimmunotherapy |
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2025-07-17T12:16:41Z |
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2025-07-17T12:16:41Z |
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1850411202966978560 |