Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes
Summary. Macrophages are important effectors of innate immunity and the key component of the tumor microenvironment strongly influencing cancer disease outcome and efficiency of cancer therapy. Moreover, recent data have shown that monocytes as macrophage precursors can impact on tumor ability to pr...
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| Дата: | 2023 |
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| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
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PH Akademperiodyka
2023
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| Онлайн доступ: | https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-1 |
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| Назва журналу: | Experimental Oncology |
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Experimental Oncology| _version_ | 1856543524467507200 |
|---|---|
| author | Patysheva, M. Stakheyeva, M. Larionova, I. Fedorov, A. Kzhyshkowska, J. Cherdyntseva, N. |
| author_facet | Patysheva, M. Stakheyeva, M. Larionova, I. Fedorov, A. Kzhyshkowska, J. Cherdyntseva, N. |
| author_sort | Patysheva, M. |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2023-10-11T16:41:40Z |
| description | Summary. Macrophages are important effectors of innate immunity and the key component of the tumor microenvironment strongly influencing cancer disease outcome and efficiency of cancer therapy. Moreover, recent data have shown that monocytes as macrophage precursors can impact on tumor ability to progression. It’s well known that although tumor-associated macrophages consist of diverse populations, in general, they have tumor-supporting activity. To change tumor-supporting state of tumor-associated macrophages toward tumor-inhibiting mode is one of prospective aims of modern cancer immunotherapy. Cytostatics seems to be possible tools to achieve this aim, because recently it has been shown that chemo- and radiotherapy possess immunomodulatory effects. Most of the findings are related to lymphocytes — T-lymphocytes and NK-cells, but not to monocyte/macrophage lineage. In the review, we have analyzed how cytostatic drugs influence the properties of monocyte/macrophage lineage cells to prospect using of chemotherapy to enhance their antitumor activity. |
| first_indexed | 2025-07-17T12:16:47Z |
| format | Article |
| id | oai:ojs2.ex.aqua-time.com.ua:article-228 |
| institution | Experimental Oncology |
| language | English |
| last_indexed | 2025-07-17T12:16:47Z |
| publishDate | 2023 |
| publisher | PH Akademperiodyka |
| record_format | ojs |
| spelling | oai:ojs2.ex.aqua-time.com.ua:article-2282023-10-11T16:41:40Z Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes Patysheva, M. Stakheyeva, M. Larionova, I. Fedorov, A. Kzhyshkowska, J. Cherdyntseva, N. cytostatic therapy, immunomodulation, monocytes, tumor progression, tumor-associated macrophages cytostatic therapy, immunomodulation, monocytes, tumor progression, tumor-associated macrophages Summary. Macrophages are important effectors of innate immunity and the key component of the tumor microenvironment strongly influencing cancer disease outcome and efficiency of cancer therapy. Moreover, recent data have shown that monocytes as macrophage precursors can impact on tumor ability to progression. It’s well known that although tumor-associated macrophages consist of diverse populations, in general, they have tumor-supporting activity. To change tumor-supporting state of tumor-associated macrophages toward tumor-inhibiting mode is one of prospective aims of modern cancer immunotherapy. Cytostatics seems to be possible tools to achieve this aim, because recently it has been shown that chemo- and radiotherapy possess immunomodulatory effects. Most of the findings are related to lymphocytes — T-lymphocytes and NK-cells, but not to monocyte/macrophage lineage. In the review, we have analyzed how cytostatic drugs influence the properties of monocyte/macrophage lineage cells to prospect using of chemotherapy to enhance their antitumor activity. Summary. Macrophages are important effectors of innate immunity and the key component of the tumor microenvironment strongly influencing cancer disease outcome and efficiency of cancer therapy. Moreover, recent data have shown that monocytes as macrophage precursors can impact on tumor ability to progression. It’s well known that although tumor-associated macrophages consist of diverse populations, in general, they have tumor-supporting activity. To change tumor-supporting state of tumor-associated macrophages toward tumor-inhibiting mode is one of prospective aims of modern cancer immunotherapy. Cytostatics seems to be possible tools to achieve this aim, because recently it has been shown that chemo- and radiotherapy possess immunomodulatory effects. Most of the findings are related to lymphocytes — T-lymphocytes and NK-cells, but not to monocyte/macrophage lineage. In the review, we have analyzed how cytostatic drugs influence the properties of monocyte/macrophage lineage cells to prospect using of chemotherapy to enhance their antitumor activity. PH Akademperiodyka 2023-06-04 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-1 10.32471/exp-oncology.2312-8852.vol-41-no-3.13597 Experimental Oncology; Vol. 41 No. 3 (2019): Experimental Oncology; 248-253 Експериментальна онкологія; Том 41 № 3 (2019): Експериментальна онкологія; 248-253 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-1/2019-3-1 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | cytostatic therapy immunomodulation monocytes tumor progression tumor-associated macrophages Patysheva, M. Stakheyeva, M. Larionova, I. Fedorov, A. Kzhyshkowska, J. Cherdyntseva, N. Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title | Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title_alt | Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title_full | Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title_fullStr | Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title_full_unstemmed | Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title_short | Cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| title_sort | cytostatic cancer therapy modulates monocyte-macrophage cell functions: how it impacts on treatment outcomes |
| topic | cytostatic therapy immunomodulation monocytes tumor progression tumor-associated macrophages |
| topic_facet | cytostatic therapy immunomodulation monocytes tumor progression tumor-associated macrophages cytostatic therapy immunomodulation monocytes tumor progression tumor-associated macrophages |
| url | https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-1 |
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