Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer
Summary. Aim: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) we...
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2023
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oai:ojs2.ex.aqua-time.com.ua:article-2292023-10-11T16:41:40Z Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer Lukianova, N.Yu. Borikun, T.V. Chekhun, V.F. breast cancer, miRNA breast cancer, miRNA Summary. Aim: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC. Summary. Aim: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC. PH Akademperiodyka 2023-06-04 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-2 10.32471/exp-oncology.2312-8852.vol-41-no-3.13615 Experimental Oncology; Vol. 41 No. 3 (2019): Experimental Oncology; 242-247 Експериментальна онкологія; Том 41 № 3 (2019): Експериментальна онкологія; 242-247 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-2/2019-3-2 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2023-10-11T16:41:40Z |
| collection |
OJS |
| language |
English |
| topic |
breast cancer miRNA |
| spellingShingle |
breast cancer miRNA Lukianova, N.Yu. Borikun, T.V. Chekhun, V.F. Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| topic_facet |
breast cancer miRNA breast cancer miRNA |
| format |
Article |
| author |
Lukianova, N.Yu. Borikun, T.V. Chekhun, V.F. |
| author_facet |
Lukianova, N.Yu. Borikun, T.V. Chekhun, V.F. |
| author_sort |
Lukianova, N.Yu. |
| title |
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| title_short |
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| title_full |
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| title_fullStr |
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| title_full_unstemmed |
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| title_sort |
tumor microenvironment-derived mirnas as prognostic markers of breast cancer |
| title_alt |
Tumor microenvironment-derived miRNAs as prognostic markers of breast cancer |
| description |
Summary. Aim: To study expression of miRNA derived from tumor microenvironment in patients with breast cancer (BC) as the aspect of tumor-host interaction. Materials and Methods: The expression levels of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2/neu) were analyzed in tissue of BC using immunohistochemical method. Relative expression levels of the miR-155, -320a, and -205 were examined in tissue and sera from BC patients using quantitative reverse transcription polymerase chain reaction. Results: Serum and tissue miR-155, -320a, and -205 levels in patients with BC are of low diagnostic value as such for differentiation of malignant and non-malignant breast neoplasms. Nevertheless, we established the relation of circulating and tissue miR-155, -320a, and -205 to lymph node metastases and basal breast cancer subtype. Conclusions: Changes of miR-155, -320a, and -205 expression in tumor tissue and sera of BC patients provide information about major clinical-pathological characteristics of BC. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-2 |
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2025-07-17T12:16:48Z |
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2025-07-17T12:16:48Z |
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