Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia

• Datum: 2023
• Hauptverfasser: Ivanivska, T.S., Sklyarenko, L.M., Zavelevich, M.P., Philchenkov, A.A., Koval, S.V., Polishchuk, A.S., Gluzman, D.F.
• Format: Artikel
• Sprache: English
• Veröffentlicht: PH Akademperiodyka 2023
• Schlagworte: acute myeloid leukemia.; bulk of blast cells; hematopoiesis; hematopoietic stem cells; leukemic stem cells; targeted therapy
• Online Zugang: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-8
• Назва журналу: Experimental Oncology

Summary. According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populations. This mini-review provides brief information on the distinctive features of LSC and blast cells in cytologically recognized types of AML. The study of different phenotypes of LSC and blast cells in AML with the aid of up-to-date flow cytometric techniques is important both for the deep insight into the mechanisms of leukemogenesis and development of novel strategies of target therapy. The urgent need for extending the diagnostic panel of monoclonal antibodies used for diagnosing AML is beyond doubt.