Immunophenotypic features of leukemic stem cells and bulk of blasts in acute myeloid leukemia

• Date: 2023
• Main Authors: Ivanivska, T.S., Sklyarenko, L.M., Zavelevich, M.P., Philchenkov, A.A., Koval, S.V., Polishchuk, A.S., Gluzman, D.F.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: acute myeloid leukemia.; bulk of blast cells; hematopoiesis; hematopoietic stem cells; leukemic stem cells; targeted therapy
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-8
• Journal Title: Experimental Oncology

Summary. According to the modern concept, leukemic stem cells (LSC) in acute myeloid leukemia (AML) are distinct from the bulk of leukemic cells in bone marrow and peripheral blood of AML patients. Nevertheless, LSC are responsible for managing all the hierarchy of the bulk of leukemic blast populat...