Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies?
Summary. The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-exc...
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| Дата: | 2023 |
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| Автор: | |
| Формат: | Стаття |
| Мова: | Англійська |
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PH Akademperiodyka
2023
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| Онлайн доступ: | https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-9 |
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| Назва журналу: | Experimental Oncology |
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Experimental Oncology| _version_ | 1856543526811074560 |
|---|---|
| author | Shuba, Ya.M. |
| author_facet | Shuba, Ya.M. |
| author_sort | Shuba, Ya.M. |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2023-10-11T16:41:40Z |
| description | Summary. The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-excitable cells. The functional significance of two other proteins, ORAI2 and ORAI3, is much less defined, although both of them participate to various extends in cell-specific modulation of SOCE as well as in supporting some of the store-independent calcium entry mechanisms. Calcium signaling becomes remodeled in cancer to promote cancer hallmarks — enhanced proliferation, resistance to apoptosis, motility and metastasizing. Although such remodeling commonly involves rearrangements of the whole molecular Ca2+-handling toolkit of the cell (Ca2+ pumps and transporters, Ca2+-binding and storage proteins, Ca2+ entry and release channels, Ca2+-dependent effectors), Ca2+ entry through Orai-based channels is especially important, as its dysregulation may contribute to several cancer hallmarks. The latter depend on the type of Ca2+-permeable channel formed by ORAI-proteins, spatiotemporal characteristics of Ca2+ signal that this channel contributes to, and the type Ca2+-dependent effector(s) targeted by this signal, all of which may be cancer-specific. By participating in global Ca2+ entry, ORAI-based SOCE may also contribute to cytosolic Ca2+ overload of cancer cells thereby playing pro-apoptotic, antineoplastic roles which can potentially be exploited for cancer treatment. This mini review examines various aspects of ORAI proteins in malignant transformation. |
| first_indexed | 2025-07-17T12:16:52Z |
| format | Article |
| id | oai:ojs2.ex.aqua-time.com.ua:article-236 |
| institution | Experimental Oncology |
| language | English |
| last_indexed | 2025-07-17T12:16:52Z |
| publishDate | 2023 |
| publisher | PH Akademperiodyka |
| record_format | ojs |
| spelling | oai:ojs2.ex.aqua-time.com.ua:article-2362023-10-11T16:41:40Z Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? Shuba, Ya.M. apoptosis, cancer, invasion, migration, ORAI1, ORAI2, ORAI3, proliferation, store-operated calcium entry apoptosis, cancer, invasion, migration, ORAI1, ORAI2, ORAI3, proliferation, store-operated calcium entry Summary. The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-excitable cells. The functional significance of two other proteins, ORAI2 and ORAI3, is much less defined, although both of them participate to various extends in cell-specific modulation of SOCE as well as in supporting some of the store-independent calcium entry mechanisms. Calcium signaling becomes remodeled in cancer to promote cancer hallmarks — enhanced proliferation, resistance to apoptosis, motility and metastasizing. Although such remodeling commonly involves rearrangements of the whole molecular Ca2+-handling toolkit of the cell (Ca2+ pumps and transporters, Ca2+-binding and storage proteins, Ca2+ entry and release channels, Ca2+-dependent effectors), Ca2+ entry through Orai-based channels is especially important, as its dysregulation may contribute to several cancer hallmarks. The latter depend on the type of Ca2+-permeable channel formed by ORAI-proteins, spatiotemporal characteristics of Ca2+ signal that this channel contributes to, and the type Ca2+-dependent effector(s) targeted by this signal, all of which may be cancer-specific. By participating in global Ca2+ entry, ORAI-based SOCE may also contribute to cytosolic Ca2+ overload of cancer cells thereby playing pro-apoptotic, antineoplastic roles which can potentially be exploited for cancer treatment. This mini review examines various aspects of ORAI proteins in malignant transformation. Summary. The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-excitable cells. The functional significance of two other proteins, ORAI2 and ORAI3, is much less defined, although both of them participate to various extends in cell-specific modulation of SOCE as well as in supporting some of the store-independent calcium entry mechanisms. Calcium signaling becomes remodeled in cancer to promote cancer hallmarks — enhanced proliferation, resistance to apoptosis, motility and metastasizing. Although such remodeling commonly involves rearrangements of the whole molecular Ca2+-handling toolkit of the cell (Ca2+ pumps and transporters, Ca2+-binding and storage proteins, Ca2+ entry and release channels, Ca2+-dependent effectors), Ca2+ entry through Orai-based channels is especially important, as its dysregulation may contribute to several cancer hallmarks. The latter depend on the type of Ca2+-permeable channel formed by ORAI-proteins, spatiotemporal characteristics of Ca2+ signal that this channel contributes to, and the type Ca2+-dependent effector(s) targeted by this signal, all of which may be cancer-specific. By participating in global Ca2+ entry, ORAI-based SOCE may also contribute to cytosolic Ca2+ overload of cancer cells thereby playing pro-apoptotic, antineoplastic roles which can potentially be exploited for cancer treatment. This mini review examines various aspects of ORAI proteins in malignant transformation. PH Akademperiodyka 2023-06-04 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-9 10.32471/exp-oncology.2312-8852.vol-41-no-3.13473 Experimental Oncology; Vol. 41 No. 3 (2019): Experimental Oncology; 200-206 Експериментальна онкологія; Том 41 № 3 (2019): Експериментальна онкологія; 200-206 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-9/2019-3-9 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | apoptosis cancer invasion migration ORAI1 ORAI2 ORAI3 proliferation store-operated calcium entry Shuba, Ya.M. Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title | Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title_alt | Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title_full | Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title_fullStr | Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title_full_unstemmed | Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title_short | Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies? |
| title_sort | ca2+ channel-forming orai proteins: cancer foes or cancer allies? |
| topic | apoptosis cancer invasion migration ORAI1 ORAI2 ORAI3 proliferation store-operated calcium entry |
| topic_facet | apoptosis cancer invasion migration ORAI1 ORAI2 ORAI3 proliferation store-operated calcium entry apoptosis cancer invasion migration ORAI1 ORAI2 ORAI3 proliferation store-operated calcium entry |
| url | https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-9 |
| work_keys_str_mv | AT shubayam ca2channelformingoraiproteinscancerfoesorcancerallies |