The dual role of ribonucleases in tumor-host relationship
Summary. Ribonucleases are enzymes that destroy RNA, play an important role in protein synthesis, epigenetic regulation of genetic activity, cell proliferation and apoptosis. Ribonucleases are important antimicrobial, antiviral and immune defense factors. Despite the same biochemical properties, the...
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2023
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oai:ojs2.ex.aqua-time.com.ua:article-2372023-10-11T16:41:40Z The dual role of ribonucleases in tumor-host relationship The dual role of ribonucleases in tumor-host relationship Shlyakhovenko, V.O. Samoylenko, О.A. ribonuclease, RNA, RNase inhibitors, tumor growth, tumor treatment ribonuclease, RNA, RNase inhibitors, tumor growth, tumor treatment Summary. Ribonucleases are enzymes that destroy RNA, play an important role in protein synthesis, epigenetic regulation of genetic activity, cell proliferation and apoptosis. Ribonucleases are important antimicrobial, antiviral and immune defense factors. Despite the same biochemical properties, they exhibit unequal, sometimes opposite biological effects. While mostly ribonucleases inhibit cell proliferation, induce apoptosis and inhibit the growth of tumors, some ribonucleases stimulate vascular growth, proliferation and tumor development. RNase inhibitors have an opposite effect. The correct use of these features of RNases can provide additional opportunities for the development of a strategy of targeted influence on tumor growth. Summary. Ribonucleases are enzymes that destroy RNA, play an important role in protein synthesis, epigenetic regulation of genetic activity, cell proliferation and apoptosis. Ribonucleases are important antimicrobial, antiviral and immune defense factors. Despite the same biochemical properties, they exhibit unequal, sometimes opposite biological effects. While mostly ribonucleases inhibit cell proliferation, induce apoptosis and inhibit the growth of tumors, some ribonucleases stimulate vascular growth, proliferation and tumor development. RNase inhibitors have an opposite effect. The correct use of these features of RNases can provide additional opportunities for the development of a strategy of targeted influence on tumor growth. PH Akademperiodyka 2023-06-04 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-10 10.32471/exp-oncology.2312-8852.vol-41-no-3.13456 Experimental Oncology; Vol. 41 No. 3 (2019): Experimental Oncology; 195-199 Експериментальна онкологія; Том 41 № 3 (2019): Експериментальна онкологія; 195-199 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-3 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-10/2019-3-10 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
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|
| datestamp_date |
2023-10-11T16:41:40Z |
| collection |
OJS |
| language |
English |
| topic |
ribonuclease RNA RNase inhibitors tumor growth tumor treatment |
| spellingShingle |
ribonuclease RNA RNase inhibitors tumor growth tumor treatment Shlyakhovenko, V.O. Samoylenko, О.A. The dual role of ribonucleases in tumor-host relationship |
| topic_facet |
ribonuclease RNA RNase inhibitors tumor growth tumor treatment ribonuclease RNA RNase inhibitors tumor growth tumor treatment |
| format |
Article |
| author |
Shlyakhovenko, V.O. Samoylenko, О.A. |
| author_facet |
Shlyakhovenko, V.O. Samoylenko, О.A. |
| author_sort |
Shlyakhovenko, V.O. |
| title |
The dual role of ribonucleases in tumor-host relationship |
| title_short |
The dual role of ribonucleases in tumor-host relationship |
| title_full |
The dual role of ribonucleases in tumor-host relationship |
| title_fullStr |
The dual role of ribonucleases in tumor-host relationship |
| title_full_unstemmed |
The dual role of ribonucleases in tumor-host relationship |
| title_sort |
dual role of ribonucleases in tumor-host relationship |
| title_alt |
The dual role of ribonucleases in tumor-host relationship |
| description |
Summary. Ribonucleases are enzymes that destroy RNA, play an important role in protein synthesis, epigenetic regulation of genetic activity, cell proliferation and apoptosis. Ribonucleases are important antimicrobial, antiviral and immune defense factors. Despite the same biochemical properties, they exhibit unequal, sometimes opposite biological effects. While mostly ribonucleases inhibit cell proliferation, induce apoptosis and inhibit the growth of tumors, some ribonucleases stimulate vascular growth, proliferation and tumor development. RNase inhibitors have an opposite effect. The correct use of these features of RNases can provide additional opportunities for the development of a strategy of targeted influence on tumor growth. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-3-10 |
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2025-07-17T12:16:53Z |
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2025-07-17T12:16:53Z |
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