Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies
Summary. Asafoetida resin has been reported for various biological activities but its use has been widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of the anticancer potential of microwave-extracted essential oil (EO) of Ferula asafoetida. Materials and Met...
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oai:ojs2.ex.aqua-time.com.ua:article-2442023-10-11T16:41:24Z Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies Verma, S. Khambhala, P. Joshi, S. Kothari, V. Patel, T. Seshadri, S. dithiolane, essential oil, F. asafoetida, hepatocellular carcinoma, HepG2, phytochemicals, SK-Hep1 dithiolane, essential oil, F. asafoetida, hepatocellular carcinoma, HepG2, phytochemicals, SK-Hep1 Summary. Asafoetida resin has been reported for various biological activities but its use has been widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of the anticancer potential of microwave-extracted essential oil (EO) of Ferula asafoetida. Materials and Methods: The phytochemical investigation and in vitro cytotoxicity assessment was carried out in two human liver cancer cell lines. The expression of NFKB1, TGFB1, TNF, CASP3 was analyzed by reverse transcription polymerase chain reaction. Results: Ferula asafoetida EO contains high concentrations of dithiolane, which possess antiproliferative activity in human liver carcinoma cell lines (HepG2 and SK-Hep1) in a dose-dependent manner. The bioactive compounds in F. asafoetida are capable of induction of apoptosis and altered NF-kB and TGF-β signalling with increase in caspase-3 and TNF-α expression. Conclusion: Further elucidation of bioactive molecules and underlying mechanisms could lead to potential intervention in liver cancer in animal models. The safety and efficacy as well as the mode of EO action in animal models would be highly crucial. Summary. Asafoetida resin has been reported for various biological activities but its use has been widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of the anticancer potential of microwave-extracted essential oil (EO) of Ferula asafoetida. Materials and Methods: The phytochemical investigation and in vitro cytotoxicity assessment was carried out in two human liver cancer cell lines. The expression of NFKB1, TGFB1, TNF, CASP3 was analyzed by reverse transcription polymerase chain reaction. Results: Ferula asafoetida EO contains high concentrations of dithiolane, which possess antiproliferative activity in human liver carcinoma cell lines (HepG2 and SK-Hep1) in a dose-dependent manner. The bioactive compounds in F. asafoetida are capable of induction of apoptosis and altered NF-kB and TGF-β signalling with increase in caspase-3 and TNF-α expression. Conclusion: Further elucidation of bioactive molecules and underlying mechanisms could lead to potential intervention in liver cancer in animal models. The safety and efficacy as well as the mode of EO action in animal models would be highly crucial. PH Akademperiodyka 2023-06-05 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-2-3 10.32471/exp-oncology.2312-8852.vol-41-no-2.12989 Experimental Oncology; Vol. 41 No. 2 (2019): Experimental Oncology; 90-94 Експериментальна онкологія; Том 41 № 2 (2019): Експериментальна онкологія; 90-94 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-2 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-2-3/2019-2-3 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
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Experimental Oncology |
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| datestamp_date |
2023-10-11T16:41:24Z |
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OJS |
| language |
English |
| topic |
dithiolane essential oil F. asafoetida hepatocellular carcinoma HepG2 phytochemicals SK-Hep1 |
| spellingShingle |
dithiolane essential oil F. asafoetida hepatocellular carcinoma HepG2 phytochemicals SK-Hep1 Verma, S. Khambhala, P. Joshi, S. Kothari, V. Patel, T. Seshadri, S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| topic_facet |
dithiolane essential oil F. asafoetida hepatocellular carcinoma HepG2 phytochemicals SK-Hep1 dithiolane essential oil F. asafoetida hepatocellular carcinoma HepG2 phytochemicals SK-Hep1 |
| format |
Article |
| author |
Verma, S. Khambhala, P. Joshi, S. Kothari, V. Patel, T. Seshadri, S. |
| author_facet |
Verma, S. Khambhala, P. Joshi, S. Kothari, V. Patel, T. Seshadri, S. |
| author_sort |
Verma, S. |
| title |
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| title_short |
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| title_full |
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| title_fullStr |
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| title_full_unstemmed |
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| title_sort |
evaluating the role of dithiolane rich fraction of ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| title_alt |
Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies |
| description |
Summary. Asafoetida resin has been reported for various biological activities but its use has been widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of the anticancer potential of microwave-extracted essential oil (EO) of Ferula asafoetida. Materials and Methods: The phytochemical investigation and in vitro cytotoxicity assessment was carried out in two human liver cancer cell lines. The expression of NFKB1, TGFB1, TNF, CASP3 was analyzed by reverse transcription polymerase chain reaction. Results: Ferula asafoetida EO contains high concentrations of dithiolane, which possess antiproliferative activity in human liver carcinoma cell lines (HepG2 and SK-Hep1) in a dose-dependent manner. The bioactive compounds in F. asafoetida are capable of induction of apoptosis and altered NF-kB and TGF-β signalling with increase in caspase-3 and TNF-α expression. Conclusion: Further elucidation of bioactive molecules and underlying mechanisms could lead to potential intervention in liver cancer in animal models. The safety and efficacy as well as the mode of EO action in animal models would be highly crucial. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-2-3 |
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