Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma

• Date: 2023
• Main Authors: Prylutska, S.V., Lynchak, O.V., Kostjukov, V.V., Evstigneev, M.P., Remeniak, O.V., Rybalchenko, V.K., Prylutskyy, Yu.I., Ritter, U., Scharff, P.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: C60 fullerene; cisplatin; hematological indices; Lewis lung carcinoma; tumor-bearing mice survival; С60-Cis-Pt nanocomplex
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-2-4
• Journal Title: Experimental Oncology

Summary. Background: Cisplatin (Cis-Pt) is a widely used anticancer drug but its therapeutic efficiency is limited by hemato-, cardio-, hepato-, nephro- and neurotoxicity. Complexation of Cis-Pt with C60 fullerene nanoparticle will allow to enhance the antitumor activity of the drug and to...