Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways

• Date: 2023
• Main Authors: Syvyk, A.E., Syvyk, T.L.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: cancer; clonal analyses; ERBB2; Her2/neu; spermatogonial stem cell; transgene expression; transgenic rat
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-2-8
• Journal Title: Experimental Oncology

Summary. Aim: The ERBB2 receptors tyrosine kinase, also known as HER2/Neu, play an essential role in early organism development and modulation of cell behavior in varieties of tissue in an adult organism. Our aim was the generation of transgenic rat spermatogonial line capable of inducible...