Aggregated proteins in malignant and benign neoplasms
Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 pat...
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PH Akademperiodyka
2023
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oai:ojs2.ex.aqua-time.com.ua:article-2612025-04-30T12:08:14Z Aggregated proteins in malignant and benign neoplasms Aggregated proteins in malignant and benign neoplasms Zabolotnyi, D.I. Belousova, A.A. Zabolotna, D.D. Savchenko, T.D. Voroshylova, N.M. Timchenko, M.D. Tsvirinko, I.R. Verevka, S.V. benign neoplasms, keloids, malignant tumors, polyposis, protein aggregation benign neoplasms, keloids, malignant tumors, polyposis, protein aggregation Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology. Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology. PH Akademperiodyka 2023-06-08 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2019-1-3 10.32471/exp-oncology.2312-8852.vol-41-no-1.12629 Experimental Oncology; Vol. 41 No. 1 (2019): Experimental Oncology; 61-68 Експериментальна онкологія; Том 41 № 1 (2019): Експериментальна онкологія; 61-68 2312-8852 1812-9269 10.32471/exp-oncology.2312-8852.vol-41-no-1 en https://exp-oncology.com.ua/index.php/Exp/article/view/2019-1-3/2019-1-3 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2025-04-30T12:08:14Z |
| collection |
OJS |
| language |
English |
| topic |
benign neoplasms keloids malignant tumors polyposis protein aggregation |
| spellingShingle |
benign neoplasms keloids malignant tumors polyposis protein aggregation Zabolotnyi, D.I. Belousova, A.A. Zabolotna, D.D. Savchenko, T.D. Voroshylova, N.M. Timchenko, M.D. Tsvirinko, I.R. Verevka, S.V. Aggregated proteins in malignant and benign neoplasms |
| topic_facet |
benign neoplasms keloids malignant tumors polyposis protein aggregation benign neoplasms keloids malignant tumors polyposis protein aggregation |
| format |
Article |
| author |
Zabolotnyi, D.I. Belousova, A.A. Zabolotna, D.D. Savchenko, T.D. Voroshylova, N.M. Timchenko, M.D. Tsvirinko, I.R. Verevka, S.V. |
| author_facet |
Zabolotnyi, D.I. Belousova, A.A. Zabolotna, D.D. Savchenko, T.D. Voroshylova, N.M. Timchenko, M.D. Tsvirinko, I.R. Verevka, S.V. |
| author_sort |
Zabolotnyi, D.I. |
| title |
Aggregated proteins in malignant and benign neoplasms |
| title_short |
Aggregated proteins in malignant and benign neoplasms |
| title_full |
Aggregated proteins in malignant and benign neoplasms |
| title_fullStr |
Aggregated proteins in malignant and benign neoplasms |
| title_full_unstemmed |
Aggregated proteins in malignant and benign neoplasms |
| title_sort |
aggregated proteins in malignant and benign neoplasms |
| title_alt |
Aggregated proteins in malignant and benign neoplasms |
| description |
Summary. Aim: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology. |
| publisher |
PH Akademperiodyka |
| publishDate |
2023 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2019-1-3 |
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2025-07-17T12:17:10Z |
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