Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma

• Date: 2023
• Main Authors: Kolesnik, D.L., Pyaskovskaya, O.N., Yakshibaeva, Yu.R., Solyanik, G.I.
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2023
• Subjects: cytotoxicity; dichloroacetate; Lewis lung carcinoma; metformin; tumor cell migration
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/2019-1-12
• Journal Title: Experimental Oncology

Summary. The use of inhibitors of energy metabolism of malignant cells is a new promising trend in the treatment of cancer patients, based on one of the unique features of the malignant cell, namely the dominance of glycolysis over oxidative phosphorylation, even in the presence of oxygen, the so-ca...