Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer
Summary. Aim: Adipokines are the proteins secreted from adipose tissue and play an important role in the control of metabolism. Dipeptidyl peptidase-4 (DPP4) is a novel adipokine with different biological role. As indicated by various studies, serum levels of DPP4 had been associated with b...
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| Дата: | 2018 |
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| Формат: | Стаття |
| Мова: | English |
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PH Akademperiodyka
2018
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-2842025-04-30T11:55:13Z Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer Abooshahab, R. Niyazi, E. Yaghmaie, P. Ghadaksaz, H.G. Hedayati, M. body-mass index, dipeptidyl peptidase 4, insulin resistance, medullary thyroid cancer, metabolic syndrome body-mass index, dipeptidyl peptidase 4, insulin resistance, medullary thyroid cancer, metabolic syndrome Summary. Aim: Adipokines are the proteins secreted from adipose tissue and play an important role in the control of metabolism. Dipeptidyl peptidase-4 (DPP4) is a novel adipokine with different biological role. As indicated by various studies, serum levels of DPP4 had been associated with body mass index (BMI), insulin resistance, metabolic syndrome and malignancy. The aim of this study was to assess the serum levels of DPP4 in patients with medullary thyroid cancer (MTC) in comparison with these in the control group. Materials and Methods: This study was performed on 45 MTC patients (24 females and 21 males) and 45 healthy controls (21 females and 24 males). DPP4 and insulin serum levels were measured by ELISA, fasting glucose serum levels by enzyme-calorimetric method and insulin resistance index (HOMA-IR) by calculation using relevant equation. BMI (kg/m2) was also calculated. Results: Our data did not demonstrate a significant difference between serum DPP4 levels in MTC and healthy group (41.06 ± 22.08 ng/ml vs 39.94 ± 20.77 ng/ml, p > 0.05). Additionally, no significant difference was found in serum insulin and HOMA-IR concentrations between MTC patients and the controls (p > 0.05). Conclusions: This study suggests that the fluctuation in the levels of DPP4 does not play an important role in prognosis, early detection and diagnosis of MTC. Furthermore, higher levels of DPP4 cannot be considered as a risk factor for MTC. Summary. Aim: Adipokines are the proteins secreted from adipose tissue and play an important role in the control of metabolism. Dipeptidyl peptidase-4 (DPP4) is a novel adipokine with different biological role. As indicated by various studies, serum levels of DPP4 had been associated with body mass index (BMI), insulin resistance, metabolic syndrome and malignancy. The aim of this study was to assess the serum levels of DPP4 in patients with medullary thyroid cancer (MTC) in comparison with these in the control group. Materials and Methods: This study was performed on 45 MTC patients (24 females and 21 males) and 45 healthy controls (21 females and 24 males). DPP4 and insulin serum levels were measured by ELISA, fasting glucose serum levels by enzyme-calorimetric method and insulin resistance index (HOMA-IR) by calculation using relevant equation. BMI (kg/m2) was also calculated. Results: Our data did not demonstrate a significant difference between serum DPP4 levels in MTC and healthy group (41.06 ± 22.08 ng/ml vs 39.94 ± 20.77 ng/ml, p > 0.05). Additionally, no significant difference was found in serum insulin and HOMA-IR concentrations between MTC patients and the controls (p > 0.05). Conclusions: This study suggests that the fluctuation in the levels of DPP4 does not play an important role in prognosis, early detection and diagnosis of MTC. Furthermore, higher levels of DPP4 cannot be considered as a risk factor for MTC. PH Akademperiodyka 2018-12-22 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-6 Experimental Oncology; Vol. 40 No. 4 (2018): Experimental Oncology; 299-302 Експериментальна онкологія; Том 40 № 4 (2018): Експериментальна онкологія; 299-302 2312-8852 1812-9269 en https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-6/2018-4-6 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2025-04-30T11:55:13Z |
| collection |
OJS |
| language |
English |
| topic |
body-mass index dipeptidyl peptidase 4 insulin resistance medullary thyroid cancer metabolic syndrome |
| spellingShingle |
body-mass index dipeptidyl peptidase 4 insulin resistance medullary thyroid cancer metabolic syndrome Abooshahab, R. Niyazi, E. Yaghmaie, P. Ghadaksaz, H.G. Hedayati, M. Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| topic_facet |
body-mass index dipeptidyl peptidase 4 insulin resistance medullary thyroid cancer metabolic syndrome body-mass index dipeptidyl peptidase 4 insulin resistance medullary thyroid cancer metabolic syndrome |
| format |
Article |
| author |
Abooshahab, R. Niyazi, E. Yaghmaie, P. Ghadaksaz, H.G. Hedayati, M. |
| author_facet |
Abooshahab, R. Niyazi, E. Yaghmaie, P. Ghadaksaz, H.G. Hedayati, M. |
| author_sort |
Abooshahab, R. |
| title |
Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| title_short |
Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| title_full |
Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| title_fullStr |
Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| title_full_unstemmed |
Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| title_sort |
serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| title_alt |
Serum level of dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer |
| description |
Summary. Aim: Adipokines are the proteins secreted from adipose tissue and play an important role in the control of metabolism. Dipeptidyl peptidase-4 (DPP4) is a novel adipokine with different biological role. As indicated by various studies, serum levels of DPP4 had been associated with body mass index (BMI), insulin resistance, metabolic syndrome and malignancy. The aim of this study was to assess the serum levels of DPP4 in patients with medullary thyroid cancer (MTC) in comparison with these in the control group. Materials and Methods: This study was performed on 45 MTC patients (24 females and 21 males) and 45 healthy controls (21 females and 24 males). DPP4 and insulin serum levels were measured by ELISA, fasting glucose serum levels by enzyme-calorimetric method and insulin resistance index (HOMA-IR) by calculation using relevant equation. BMI (kg/m2) was also calculated. Results: Our data did not demonstrate a significant difference between serum DPP4 levels in MTC and healthy group (41.06 ± 22.08 ng/ml vs 39.94 ± 20.77 ng/ml, p > 0.05). Additionally, no significant difference was found in serum insulin and HOMA-IR concentrations between MTC patients and the controls (p > 0.05). Conclusions: This study suggests that the fluctuation in the levels of DPP4 does not play an important role in prognosis, early detection and diagnosis of MTC. Furthermore, higher levels of DPP4 cannot be considered as a risk factor for MTC. |
| publisher |
PH Akademperiodyka |
| publishDate |
2018 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-6 |
| work_keys_str_mv |
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| first_indexed |
2025-07-17T12:17:24Z |
| last_indexed |
2025-07-17T12:17:24Z |
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