FoxP3 gene polymorphism is associated with breast cancer in Iranian patients

• Дата: 2018
• Автори: Arabpour, F., Shafizad, A., Rahimzadeh, M., Norouzian, M., Naderi, N.
• Формат: Стаття
• Мова: English
• Опубліковано: PH Akademperiodyka 2018
• Теми: breast cancer; FOXP3; polymorphism; Treg cells
• Онлайн доступ: https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-8
• Назва журналу: Experimental Oncology

Summary. Aim: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. Materials and Methods: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. Results: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548C>A polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). Conclusion: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population.