FoxP3 gene polymorphism is associated with breast cancer in Iranian patients
Summary. Aim: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence...
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| Дата: | 2018 |
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| Мова: | English |
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PH Akademperiodyka
2018
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-2862025-04-30T11:55:13Z FoxP3 gene polymorphism is associated with breast cancer in Iranian patients FoxP3 gene polymorphism is associated with breast cancer in Iranian patients Arabpour, F. Shafizad, A. Rahimzadeh, M. Norouzian, M. Naderi, N. breast cancer, FOXP3, polymorphism, Treg cells breast cancer, FOXP3, polymorphism, Treg cells Summary. Aim: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. Materials and Methods: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. Results: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548C>A polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). Conclusion: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population. Summary. Aim: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. Materials and Methods: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. Results: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548C>A polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). Conclusion: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population. PH Akademperiodyka 2018-12-22 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-8 Experimental Oncology; Vol. 40 No. 4 (2018): Experimental Oncology; 309-314 Експериментальна онкологія; Том 40 № 4 (2018): Експериментальна онкологія; 309-314 2312-8852 1812-9269 en https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-8/2018-4-8 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2025-04-30T11:55:13Z |
| collection |
OJS |
| language |
English |
| topic |
breast cancer FOXP3 polymorphism Treg cells |
| spellingShingle |
breast cancer FOXP3 polymorphism Treg cells Arabpour, F. Shafizad, A. Rahimzadeh, M. Norouzian, M. Naderi, N. FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| topic_facet |
breast cancer FOXP3 polymorphism Treg cells breast cancer FOXP3 polymorphism Treg cells |
| format |
Article |
| author |
Arabpour, F. Shafizad, A. Rahimzadeh, M. Norouzian, M. Naderi, N. |
| author_facet |
Arabpour, F. Shafizad, A. Rahimzadeh, M. Norouzian, M. Naderi, N. |
| author_sort |
Arabpour, F. |
| title |
FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| title_short |
FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| title_full |
FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| title_fullStr |
FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| title_full_unstemmed |
FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| title_sort |
foxp3 gene polymorphism is associated with breast cancer in iranian patients |
| title_alt |
FoxP3 gene polymorphism is associated with breast cancer in Iranian patients |
| description |
Summary. Aim: Breast cancer (BC) is one of the leading causes of cancer death among women. Recent studies have characterized FoxP3 as a marker of regulatory T cells and an X-linked tumor suppressor gene, which is involved in the pathogenesis of BC. Therefore, we investigated the potential influence of three single-nucleotide polymorphisms (SNPs) of FoxP3 gene on the development of BC in Iranian women. Materials and Methods: The association between FoxP3 rs2232365, rs3761548 and rs4824747 polymorphisms and BC risk was assessed in 124 BC patients and 198 healthy controls using sequence-specific primers. Results: We identified significant difference of rs3761548 in both allele and genotype frequencies between cases and control groups. Our results showed that individuals carrying FoxP3 rs3761548 AA genotype had about 4.3-fold increased risk of BC compared with CC carriers. No significant association was found between rs3761548C>A polymorphism and clinical outcome parameters (age of onset, tumor size, lymph nodes metastasis, tumor stage, progesterone receptor status, estrogen receptor status, Ki-67 status, HER-2 status and duration of disease). Conclusion: This study has provided the first genetic data on the FoxP3 gene polymorphism in south of Iran and proposes the rs3761548 polymorphism of FoxP3 gene as a risk factor, but not a prognostic marker in the development of BC in Iranian population. |
| publisher |
PH Akademperiodyka |
| publishDate |
2018 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-8 |
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2025-07-17T12:17:25Z |
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