The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model
Summary. Aim: To investigate the effect of chicken embryo proteins (CEP) as a prototype of xenogeneic vaccine on immune reactions in mice immunized after Lewis lung carcinoma (LLC) surgical removal. Materials and Methods: C57Bl male mice were immunized on days 1, 8, and 15 after surgical removal of...
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| Дата: | 2018 |
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| Мова: | English |
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PH Akademperiodyka
2018
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| Назва журналу: | Experimental Oncology |
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oai:ojs2.ex.aqua-time.com.ua:article-2882025-04-30T11:55:13Z The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model Symchych, T.V. Fedosova, N.I. Karaman, O.M. Voyeykova, I.M. Didenko, G.V. chicken embryo proteins, Lewis lung carcinoma, xenogeneic anticancer vaccine chicken embryo proteins, Lewis lung carcinoma, xenogeneic anticancer vaccine Summary. Aim: To investigate the effect of chicken embryo proteins (CEP) as a prototype of xenogeneic vaccine on immune reactions in mice immunized after Lewis lung carcinoma (LLC) surgical removal. Materials and Methods: C57Bl male mice were immunized on days 1, 8, and 15 after surgical removal of LLC. The immune response was assessed on days 7, 14, 21 and 28 after tumor resection. Cytotoxic activity of natural killer cells (NK) and cytotoxic T-lymphocytes as well as antibody dependent cellular cytotoxicity was estimated in MTT-assay; specific antibodies were detected in ELISA; lymphocyte proliferation was tested in reaction of in vitro blast transformation. Results: None of the immunized mice developed LLC metastases. Immunization with CEP seems to prevent the potential decrease in NK cell cytotoxic activity and spontaneous blast transformation activity of lymphocytes following the surgically induced stress. Further research on improving immunization schedule and elucidating the mechanisms of NK modulation with CEP is needed. Summary. Aim: To investigate the effect of chicken embryo proteins (CEP) as a prototype of xenogeneic vaccine on immune reactions in mice immunized after Lewis lung carcinoma (LLC) surgical removal. Materials and Methods: C57Bl male mice were immunized on days 1, 8, and 15 after surgical removal of LLC. The immune response was assessed on days 7, 14, 21 and 28 after tumor resection. Cytotoxic activity of natural killer cells (NK) and cytotoxic T-lymphocytes as well as antibody dependent cellular cytotoxicity was estimated in MTT-assay; specific antibodies were detected in ELISA; lymphocyte proliferation was tested in reaction of in vitro blast transformation. Results: None of the immunized mice developed LLC metastases. Immunization with CEP seems to prevent the potential decrease in NK cell cytotoxic activity and spontaneous blast transformation activity of lymphocytes following the surgically induced stress. Further research on improving immunization schedule and elucidating the mechanisms of NK modulation with CEP is needed. PH Akademperiodyka 2018-12-22 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-10 Experimental Oncology; Vol. 40 No. 4 (2018): Experimental Oncology; 275-281 Експериментальна онкологія; Том 40 № 4 (2018): Експериментальна онкологія; 275-281 2312-8852 1812-9269 en https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-10/2018-4-10 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| institution |
Experimental Oncology |
| baseUrl_str |
|
| datestamp_date |
2025-04-30T11:55:13Z |
| collection |
OJS |
| language |
English |
| topic |
chicken embryo proteins Lewis lung carcinoma xenogeneic anticancer vaccine |
| spellingShingle |
chicken embryo proteins Lewis lung carcinoma xenogeneic anticancer vaccine Symchych, T.V. Fedosova, N.I. Karaman, O.M. Voyeykova, I.M. Didenko, G.V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| topic_facet |
chicken embryo proteins Lewis lung carcinoma xenogeneic anticancer vaccine chicken embryo proteins Lewis lung carcinoma xenogeneic anticancer vaccine |
| format |
Article |
| author |
Symchych, T.V. Fedosova, N.I. Karaman, O.M. Voyeykova, I.M. Didenko, G.V. |
| author_facet |
Symchych, T.V. Fedosova, N.I. Karaman, O.M. Voyeykova, I.M. Didenko, G.V. |
| author_sort |
Symchych, T.V. |
| title |
The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| title_short |
The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| title_full |
The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| title_fullStr |
The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| title_full_unstemmed |
The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| title_sort |
effects of early postoperative immunization with xenogeneic embryo proteins on lewis lung carcinoma model |
| title_alt |
The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model |
| description |
Summary. Aim: To investigate the effect of chicken embryo proteins (CEP) as a prototype of xenogeneic vaccine on immune reactions in mice immunized after Lewis lung carcinoma (LLC) surgical removal. Materials and Methods: C57Bl male mice were immunized on days 1, 8, and 15 after surgical removal of LLC. The immune response was assessed on days 7, 14, 21 and 28 after tumor resection. Cytotoxic activity of natural killer cells (NK) and cytotoxic T-lymphocytes as well as antibody dependent cellular cytotoxicity was estimated in MTT-assay; specific antibodies were detected in ELISA; lymphocyte proliferation was tested in reaction of in vitro blast transformation. Results: None of the immunized mice developed LLC metastases. Immunization with CEP seems to prevent the potential decrease in NK cell cytotoxic activity and spontaneous blast transformation activity of lymphocytes following the surgically induced stress. Further research on improving immunization schedule and elucidating the mechanisms of NK modulation with CEP is needed. |
| publisher |
PH Akademperiodyka |
| publishDate |
2018 |
| url |
https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-10 |
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2025-07-17T12:17:27Z |
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2025-07-17T12:17:27Z |
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