Clinical significance of serum caveolin-1 levels in gastric cancer patients
Summary. Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examin...
Збережено в:
| Дата: | 2018 |
|---|---|
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
PH Akademperiodyka
2018
|
| Теми: | |
| Онлайн доступ: | https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-11 |
| Теги: |
Додати тег
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|
| Назва журналу: | Experimental Oncology |
Репозитарії
Experimental Oncology| _version_ | 1856543554981068800 |
|---|---|
| author | Tas, F. Karabulut, S. Erturk, K. Duranyildiz, D. |
| author_facet | Tas, F. Karabulut, S. Erturk, K. Duranyildiz, D. |
| author_sort | Tas, F. |
| baseUrl_str | |
| collection | OJS |
| datestamp_date | 2025-04-30T11:55:13Z |
| description | Summary. Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p < 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p > 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer. |
| first_indexed | 2025-07-17T12:17:27Z |
| format | Article |
| id | oai:ojs2.ex.aqua-time.com.ua:article-289 |
| institution | Experimental Oncology |
| language | English |
| last_indexed | 2025-07-17T12:17:27Z |
| publishDate | 2018 |
| publisher | PH Akademperiodyka |
| record_format | ojs |
| spelling | oai:ojs2.ex.aqua-time.com.ua:article-2892025-04-30T11:55:13Z Clinical significance of serum caveolin-1 levels in gastric cancer patients Clinical significance of serum caveolin-1 levels in gastric cancer patients Tas, F. Karabulut, S. Erturk, K. Duranyildiz, D. caveolin-1, diagnostic., gastric cancer, serum caveolin-1, diagnostic., gastric cancer, serum Summary. Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p < 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p > 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer. Summary. Caveolin-1 plays a significant role in the pathogenesis of various carcinomas and its expression affects the survival of cancer patients. However, the molecular function of caveolin-1 and its possible clinical importance has remained uncertain in gastric cancer. No clinical trial has examined serum caveolin-1 levels in gastric cancer patients so far, instead all available results were provided from studies conducted on tissue samples. In the current study, we analyzed the soluble serum caveolin-1 levels in gastric cancer patients, and specified its associations with the clinical factors and prognosis. Material and Methods: Sixty-three patients with pathologically confirmed gastric cancer were enrolled into the trial. Serum caveolin-1 concentrations were detected by ELISA method. Thirty healthy subjects were also included in the study. Results: The median age of patients was 62 years, ranging from 28 to 82 years. The serum caveolin-1 levels in gastric cancer patients were significantly higher than those in control group (p < 0.001). The common clinical parameters including patient age, sex, lesion localization, histopathology, histological grade, disease stage, and various serum tumor markers (e.g. LDH, CEA, and CA 19.9) were not found to be associated with serum caveolin-1 levels (p > 0.05). Similarly, no correlation existed between serum caveolin-1 concentration and chemotherapy responsiveness (p = 0.93). Furthermore, serum caveolin-1 level was not found to have a prognostic role (p = 0.16). Conclusion: Even though it is neither predictive nor prognostic, serum caveolin-1 level may be a valuable diagnostic indicator in patients with gastric cancer. PH Akademperiodyka 2018-12-22 Article Article application/pdf https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-11 Experimental Oncology; Vol. 40 No. 4 (2018): Experimental Oncology; 323-327 Експериментальна онкологія; Том 40 № 4 (2018): Експериментальна онкологія; 323-327 2312-8852 1812-9269 en https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-11/2018-4-11 Copyright (c) 2023 Experimental Oncology https://creativecommons.org/licenses/by-nc/4.0/ |
| spellingShingle | caveolin-1 diagnostic. gastric cancer serum Tas, F. Karabulut, S. Erturk, K. Duranyildiz, D. Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title | Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title_alt | Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title_full | Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title_fullStr | Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title_full_unstemmed | Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title_short | Clinical significance of serum caveolin-1 levels in gastric cancer patients |
| title_sort | clinical significance of serum caveolin-1 levels in gastric cancer patients |
| topic | caveolin-1 diagnostic. gastric cancer serum |
| topic_facet | caveolin-1 diagnostic. gastric cancer serum caveolin-1 diagnostic. gastric cancer serum |
| url | https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-11 |
| work_keys_str_mv | AT tasf clinicalsignificanceofserumcaveolin1levelsingastriccancerpatients AT karabuluts clinicalsignificanceofserumcaveolin1levelsingastriccancerpatients AT erturkk clinicalsignificanceofserumcaveolin1levelsingastriccancerpatients AT duranyildizd clinicalsignificanceofserumcaveolin1levelsingastriccancerpatients |