Vitamin Е activates expression of С/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells

• Datum: 2018
• Hauptverfasser: Shvachko, L.P., Zavelevich, M.P., Gluzman, D.F., Kravchuk, I.V., Telegeev, G.D.
• Format: Artikel
• Sprache: English
• Veröffentlicht: PH Akademperiodyka 2018
• Schlagworte: C/EBP alpha transcription factor; chronic myeloid leukemia; G-CSFR; granulocytic differentiation; vitamin E.
• Online Zugang: https://exp-oncology.com.ua/index.php/Exp/article/view/2018-4-13
• Назва журналу: Experimental Oncology

Summary. Background: Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder associated with the activity of BCR-ABL fusion oncogene. Tyrosine kinase inhibitors are the current treatment of CML, but secondary mutations finally contribute to therapy resistance and blast crisis of...