СУЛЬФОРАФАН ПРИГНІЧУЄ ГЕПАТОЦЕЛЮЛЯРНУ КАРЦИНОМУ У МИШЕЙ ШЛЯХОМ АКТИВАЦІЇ P53, ЗМЕНШЕННЯ ОКСИДАТИВНОГО СТРЕСУ ТА ІНГІБУВАННЯ АНГІОГЕНЕЗУ

• Published in: Експериментальна онкологія
• Date: 2026
• Volume: 48
• Issue: 2
• Pages: 120-132
• ISSN: 2312-8852
• Author Affiliations: Kholoud A. Omran — Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt; Yomna I. Mahmoud — Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt; Asmaa A. Mahmoud — Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt; Nagui H. Fares — Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt
• Main Authors: A. Omran, Kholoud, I. Mahmoud, Yomna, A. Mahmoud, Asmaa, H. Fares, Nagui
• Format: Article
• Language: English
• Published: PH Akademperiodyka 2026
• Subjects: гепатоцелюлярна карцинома; сульфорафан; Bax; Bcl-2; VEGF; PCNA; p53; оксидативний стрес; миші
• Online Access: https://exp-oncology.com.ua/index.php/Exp/article/view/644
• Journal Title: Experimental Oncology

Background. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Sulforaphane (SF) is a natural isothiocyanate that exhibits anticarcinogenic activity against various cancer cells in vivo and in vitro, with no observed side effects. It also has a prophylactic effect against ea...