Утворення комплексiв молекул пероксиду водню з ДНК
A possibility for hydrogen peroxide molecules to form stable complexes with atomic groups in the DNA backbone under the irradiation of the cell medium with high-energy ions has been studied. The energy of complexes is estimated, by taking the electrostatic and van der Waals interactions into account...
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| Date: | 2019 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English Ukrainian |
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Publishing house "Academperiodika"
2019
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| Online Access: | https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2019102 |
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| Journal Title: | Ukrainian Journal of Physics |
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Ukrainian Journal of Physics| _version_ | 1863131271848263680 |
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| author | Piatnytskyi, D. V. Zdorevsky, O. O. Perepelytsya, S. M. Volkov, S. N. |
| author_facet | Piatnytskyi, D. V. Zdorevsky, O. O. Perepelytsya, S. M. Volkov, S. N. |
| author_sort | Piatnytskyi, D. V. |
| baseUrl_str | https://ujp.bitp.kiev.ua/index.php/ujp/oai |
| collection | OJS |
| datestamp_date | 2019-04-16T20:20:52Z |
| description | A possibility for hydrogen peroxide molecules to form stable complexes with atomic groups in the DNA backbone under the irradiation of the cell medium with high-energy ions has been studied. The energy of complexes is estimated, by taking the electrostatic and van der Waals interactions into account in the framework of the atom-atom potential function method. The interaction with metal counterions, which neutralize the surface charge of a macromolecule under natural conditions, is also taken into consideration. Stable configurations are determined for various complexes consisting of the atoms belonging to a DNA phosphate group, H2O2 and H2O molecules, and a Na+ metal ion. The complexes of hydrogen peroxide molecules with DNA phosphate groups and a counterion are shown to be not less stable than their complexes with water molecules. The attachment of an H2O2 molecule to a phosphate group of the double helix backbone can block the processes of DNA biological functioning and can deactivate the genetic mechanism of a cell. |
| doi_str_mv | 10.15407/ujpe61.03.0219 |
| first_indexed | 2025-10-02T01:15:50Z |
| format | Article |
| id | ujp2-article-2019102 |
| institution | Ukrainian Journal of Physics |
| keywords_txt_mv | keywords |
| language | English Ukrainian |
| last_indexed | 2025-10-02T01:15:50Z |
| publishDate | 2019 |
| publisher | Publishing house "Academperiodika" |
| record_format | ojs |
| spelling | ujp2-article-20191022019-04-16T20:20:52Z Formation of Complexes of Hydrogen Peroxide Molecules with DNA Утворення комплексiв молекул пероксиду водню з ДНК Piatnytskyi, D. V. Zdorevsky, O. O. Perepelytsya, S. M. Volkov, S. N. DNA hydrogen peroxide Bragg peak ionic therapy - ДНК пероксид водню пiк Брегга iонна терапiя A possibility for hydrogen peroxide molecules to form stable complexes with atomic groups in the DNA backbone under the irradiation of the cell medium with high-energy ions has been studied. The energy of complexes is estimated, by taking the electrostatic and van der Waals interactions into account in the framework of the atom-atom potential function method. The interaction with metal counterions, which neutralize the surface charge of a macromolecule under natural conditions, is also taken into consideration. Stable configurations are determined for various complexes consisting of the atoms belonging to a DNA phosphate group, H2O2 and H2O molecules, and a Na+ metal ion. The complexes of hydrogen peroxide molecules with DNA phosphate groups and a counterion are shown to be not less stable than their complexes with water molecules. The attachment of an H2O2 molecule to a phosphate group of the double helix backbone can block the processes of DNA biological functioning and can deactivate the genetic mechanism of a cell. Дослiджено можливiсть утворення стабiльних комплексiв фосфатних груп ДНК з молекулами пероксиду водню пiд час опромiнення високоенергетичними iонами середовища бiологiчних клiтин. Енергiя комплексiв визначалася з урахуванням електростатичних i ван-дер-ваальсiвських взаємодiй за методом атом-атомних потенцiальних функцiй. Враховувалася взаємодiя з протиiонами металу, якi в природних умовах нейтралiзують заряд фосфатних груп ДНК. Визначено стабiльнi конфiгурацiї рiзних комплексiв, якi складаються з атомiв фосфатної групи остова ДНК, молекул H2O2 i H2O, та iона металу Na+. Показано, що комплекси молекул пероксиду водню з фосфатними групами ДНК i протиiоном є не менш стабiльними, нiж вiдповiднi комплекси з молекулами води. Приєднання молекули H2O2 до фосфатної групи остова подвiйної спiралi може блокувати процеси бiологiчного функцiонування ДНК i призводити до дезактивацiї генетичного апарату клiтини. Publishing house "Academperiodika" 2019-01-06 Article Article Peer-reviewed Рецензована стаття application/pdf application/pdf https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2019102 10.15407/ujpe61.03.0219 Ukrainian Journal of Physics; Vol. 61 No. 3 (2016); 219 Український фізичний журнал; Том 61 № 3 (2016); 219 2071-0194 2071-0186 10.15407/ujpe61.03 en uk https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2019102/1002 https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2019102/1003 Copyright (c) 2019 Bogolyubov Institute for Theoretical Physics, National Academy of Sciences of Ukraine |
| spellingShingle | ДНК пероксид водню пiк Брегга iонна терапiя Piatnytskyi, D. V. Zdorevsky, O. O. Perepelytsya, S. M. Volkov, S. N. Утворення комплексiв молекул пероксиду водню з ДНК |
| title | Утворення комплексiв молекул пероксиду водню з ДНК |
| title_alt | Formation of Complexes of Hydrogen Peroxide Molecules with DNA |
| title_full | Утворення комплексiв молекул пероксиду водню з ДНК |
| title_fullStr | Утворення комплексiв молекул пероксиду водню з ДНК |
| title_full_unstemmed | Утворення комплексiв молекул пероксиду водню з ДНК |
| title_short | Утворення комплексiв молекул пероксиду водню з ДНК |
| title_sort | утворення комплексiв молекул пероксиду водню з днк |
| topic | ДНК пероксид водню пiк Брегга iонна терапiя |
| topic_facet | DNA hydrogen peroxide Bragg peak ionic therapy - ДНК пероксид водню пiк Брегга iонна терапiя |
| url | https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2019102 |
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