Гідрогелеві композити з наночастинками срібла для біомедичного застосування

• Main Authors: Nadtoka, O., Kutsevol, N., Bezugla, T., Virych, P., Naumenko, A.
• Format: Article
• Language: English
• Published: Publishing house "Academperiodika" 2020
• Subjects: silver nanoparticles; hydrogel; polyacrylamide; TEM; FTIR; UV–Vis spectroscopy; -
• Online Access: https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2020010

Polyacrylamide and dextran-graft-polyacrylamide hydrogels are prepared and used as nanoreactors and networks for the synthesis of silver nanoparticles (AgNPs). Photochemical generation of AgNPs is carried out under UV-irradiation of Ag+ ions in swollen hydrogels of different cross-linking densities. The obtained hydrogels and hydrogel/AgNPs composites are characterized by TEM, FTIR, and UV–Vis spectroscopy. Swelling studies have shown a relationship between the structure of the hydrogels and their ability to swell. It is shown that the presence of AgNPs in the polymer network leads to a decrease of the swelling capacity. An increase in the cross-linking density leads to an expansion of the AgNPs size distribution for both types of hydrogels. All synthesized hydrogel-silver nanoparticle composites have shown a high activity in the growth retardation of Staphylococcus aureus microorganisms.