Модифікація структури алкалоїдів препарату Conium фулеренами С60
The antineoplastic drug Conium, whose active components are piperidine alkaloids, and the possibility of a modification of its properties by fullerenes C60 are studied. The IR spectra of the mixture of the drug Conium and a fullerene water solution are obtained. The spectral manifestation of the for...
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| Date: | 2012 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Publishing house "Academperiodika"
2012
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| Subjects: | |
| Online Access: | https://ujp.bitp.kiev.ua/index.php/ujp/article/view/2021231 |
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| Journal Title: | Ukrainian Journal of Physics |
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Ukrainian Journal of Physics| Summary: | The antineoplastic drug Conium, whose active components are piperidine alkaloids, and the possibility of a modification of its properties by fullerenes C60 are studied. The IR spectra of the mixture of the drug Conium and a fullerene water solution are obtained. The spectral manifestation of the formation of a complex of fullerene with one of the alkaloids, namely γ-coniceine, is detected. The existence of the complex and its spectral characteristics are confirmed by quantum-chemical computations with a Gaussian program. Moreover, the IR spectra are calculated, and the conformations of γ-coniceine are studied. |
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