Genotoxic factors associated with the development of receptor-negative breast cancer: potential role of the phenomenon of switching of estrogen effects

• Main Authors: Berstein, L.M., Tsyrlina, E.V., Poroshina, T.E., Levina, V.V., Vasilyev, D.A., Kovalenko, I.G., Semiglazov, V.F.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
• Series: Experimental Oncology
• Subjects: Original contributions
• Online Access: http://dspace.nbuv.gov.ua/handle/123456789/134529

Aim: About 30–40% of breast cancers lack steroid receptors (ER and/or PR) at diagnosis that worsen prognosis and limit the usage of hormone therapy. The aim of this paper has been to study the role of DNA-damaging factors as the potential modifiers of the receptor-negative tumors incidence. Material...