Genotoxic factors associated with the development of receptor-negative breast cancer: potential role of the phenomenon of switching of estrogen effects

• Datum: 2006
• Hauptverfasser: Berstein, L.M., Tsyrlina, E.V., Poroshina, T.E., Levina, V.V., Vasilyev, D.A., Kovalenko, I.G., Semiglazov, V.F.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
• Schriftenreihe: Experimental Oncology
• Schlagworte: Original contributions
• Online Zugang: http://dspace.nbuv.gov.ua/handle/123456789/134529
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Genotoxic factors associated with the development of receptor-negative breast cancer: potential role of the phenomenon of switching of estrogen effects / L.M. Berstein, E.V. Tsyrlina, T.E. Poroshina, V.V. Levina, D.A. Vasilyev, I.G. Kovalenko, V.F. Semiglazov // Experimental Oncology. — 2006. — Т. 28, № 1. — С. 64-69. — Бібліогр.: 32 назв. — англ.

Aim: About 30–40% of breast cancers lack steroid receptors (ER and/or PR) at diagnosis that worsen prognosis and limit the usage of hormone therapy. The aim of this paper has been to study the role of DNA-damaging factors as the potential modifiers of the receptor-negative tumors incidence. Material...