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The study of possibility to elevate antitumor activity and decrease of systemic toxic effects of cisplatin by its binding with deliganded albumin

The study of possibility to elevate antitumor activity and decrease of systemic toxic effects of cisplatin by its binding with deliganded albumin

Aim: To evaluate antitumor and toxic action of cisplatin (CP) in non-bound form and in a complex with deliganded albumin. Methods: To study complex-formation between CP and albumin, differential scanning and isothermic flow microcalorimetry were used. For quantitive evaluation of albumin-bound CP, t...

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Main Authors: Sakhno, L.A., Sarnatskaya, V.V., Yushko, L.A., Melnikov, O.R., Momot, V.Ya., Korneeva, L.N., Svintsiskiy, V.S., Korotich, V.G., Nechitaylo, I.I., Nikolaev, V.G.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2006
Series:Experimental Oncology
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Online Access:http://dspace.nbuv.gov.ua/handle/123456789/137586
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http://dspace.nbuv.gov.ua/handle/123456789/137586

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