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Hypoxia enhances antitumor activity of dichloroacetate

Hypoxia enhances antitumor activity of dichloroacetate

It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy metabolism of tumor cells from aerobic glycolysis towards oxidative phosphoryla...

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Bibliographic Details
Main Authors: Kolesnik, D.L., Pyaskovskaya, O.N., Boichuk, I.V., Solyanik, G.I.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
Series:Experimental Oncology
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Online Access:http://dspace.nbuv.gov.ua/handle/123456789/145373
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http://dspace.nbuv.gov.ua/handle/123456789/145373

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