NGS-based identification of druggable alterations and signaling pathways – hepatocellular carcinoma case report

• Дата: 2015
• Автори: Kotelnikova, E.A., Logacheva, M.D., Nabieva, E.R., Pyatnitskiy, M.A., Vinogradov, D.V., Makarova, A.S., Demin, A.V., Paleeva, A.G., Kremenetskaya, O.S., Penin, A.A., Klepikova, A.V., Kasianov, A.S., Shavochkina, D.A., Kudashkin, N.E., Patyutko, Yu.I., Mugue, N.S., Kondrashov, A.S., Lazarevich, N.L
• Формат: Стаття
• Мова: English
• Опубліковано: Інститут молекулярної біології і генетики НАН України 2015
• Назва видання: Вiopolymers and Cell
• Теми: Genomics, Transcriptomics and Proteomics
• Онлайн доступ: http://dspace.nbuv.gov.ua/handle/123456789/152692
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: NGS-based identification of druggable alterations and signaling pathways – hepatocellular carcinoma case report / E.A. Kotelnikova, M.D. Logacheva, E.R. Nabieva, M.A. Pyatnitskiy, D.V. Vinogradov, A.S. Makarova, A.V. Demin, A.G. Paleeva, O.S. Kremenetskaya, A.A. Penin, A.V. Klepikova, A.S. Kasianov, D.A. Shavochkina, N.E. Kudashkin, Yu.I. Patyutko, N.S. Mugue, A.S. Kondrashov, N.L Lazarevich // Вiopolymers and Cell. — 2015. — Т. 31, № 6. — С. 436-446. — Бібліогр.: 33 назв. — англ.

Aim. To identify potential cancer driving or clinically relevant molecular events for a patient with hepatocellular carcinoma. Methods. In order to achieve this goal, we performed RNA-seq and exome sequencing for the tumor tissue and its matched control. We annotated the alterations found using seve...