NGS-based identification of druggable alterations and signaling pathways – hepatocellular carcinoma case report

• Main Authors: Kotelnikova, E.A., Logacheva, M.D., Nabieva, E.R., Pyatnitskiy, M.A., Vinogradov, D.V., Makarova, A.S., Demin, A.V., Paleeva, A.G., Kremenetskaya, O.S., Penin, A.A., Klepikova, A.V., Kasianov, A.S., Shavochkina, D.A., Kudashkin, N.E., Patyutko, Yu.I., Mugue, N.S., Kondrashov, A.S., Lazarevich, N.L
• Format: Article
• Language: English
• Published: Інститут молекулярної біології і генетики НАН України 2015
• Series: Вiopolymers and Cell
• Subjects: Genomics, Transcriptomics and Proteomics
• Online Access: http://dspace.nbuv.gov.ua/handle/123456789/152692

Aim. To identify potential cancer driving or clinically relevant molecular events for a patient with hepatocellular carcinoma. Methods. In order to achieve this goal, we performed RNA-seq and exome sequencing for the tumor tissue and its matched control. We annotated the alterations found using seve...