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Correlation of mutagenesis level with expression of reparative enzyme O6-methylguanine DNA methyltransferase during establishment of cell lines in vitro

Correlation of mutagenesis level with expression of reparative enzyme O6-methylguanine DNA methyltransferase during establishment of cell lines in vitro

Long-term cultivation of cell lines inevitably leads to genetic and epigenetic changes. The aim of this work was a comparative analysis of karyotype and level of the expression of reparative enzyme O6-methylguanine-DNA- methyltransferase (MGMT) at different stages of establishment and stabilization...

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Bibliographic Details
Main Authors: Macewicz, L.L., Kushniruk, V.O., Iatsyshyna, A.P., Kotsarenko, K.V., Lylo, V.V., Akopyan, G.R., Huleuk, N.L., Mykytenko, D.O., Lukash, L.L.
Format: Article
Language:English
Published: Інститут молекулярної біології і генетики НАН України 2013
Series:Вiopolymers and Cell
Subjects:
Genomics, Transcriptomics and Proteomics
Online Access:http://dspace.nbuv.gov.ua/handle/123456789/153665
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http://dspace.nbuv.gov.ua/handle/123456789/153665

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